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Overview

Uniprot IDQ86Y13
Protein NameE3 ubiquitin-protein ligase DZIP3
Gene NameDZIP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
824 DNEIKNLKEQLSMKR
830 LKEQLSMKRSQWEME

Function

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA

Protein Sequence

10 MDSLPDEFFV 20 RHPAVEDQRK 30 EETENKLEKS 40 SGQLNKQEND 50 IPTDLVPVNL 60 LLEVKKLLNA 70 INTLPKGVVP 80 HIKKFLQEDF 90 SFQTMQREVA 100 ANSQNGEEIV 110 PALTLRFLIT 120 QLEAALRNIQ 130 AGNYTAHQIN 140 IGYYLTLLFL 150 YGVALTERGK 160 KEDYTEAENK 170 FLVMKMMIQE 180 NEICENFMSL 190 VYFGRGLLRC 200 AQKRYNGGLL 210 EFHKSLQEIG 220 DKNDHWFDID 230 PTEDEDLPTT 240 FKDLLNNFIK 250 TTESNIMKQT 260 ICSYLDCERS 270 CEADILKNTS 280 YKGFFQLMCS 290 KSCCVYFHKI 300 CWKKFKNLKY 310 PGENDQSFSG 320 KKCLKEGCTG 330 DMVRMLQCDV 340 PGIVKILFEV 350 VRKDEYITIE 360 NLGASYRKLI 370 SLKITDTDIR 380 PKISLKFNTK 390 DEMPIFKLDY 400 NYFYHLLHII 410 IISGTDIVRQ 420 IFDEAMPPPL 430 LKKELLIHKN 440 VLESYYNHLW 450 TNHPLGGSWH 460 LLYPPNKELP 470 QSKQFDLCLL 480 LALIKHLNVF 490 PAPKKGWNME 500 PPSSDISKSA 510 DILRLCKYRD 520 ILLSEILMNG 530 LTESQFNSIW 540 KKVSDILLRL 550 GMMQEDIDKV 560 KENPIENISL 570 DYHQLSVYLG 580 IPVPEIIQRM 590 LSCYQQGIAL 600 QSITGSQRIE 610 IEELQNEEEE 620 LSPPLMEYNI 630 NVKSHPEIQF 640 AEINKDGTSI 650 PSESSTESLK 660 DLQEVKSKQR 670 KKKKTKNKKN 680 KDSKEDQVPY 690 VVEKEEQLRK 700 EQANPHSVSR 710 LIKDDASDVQ 720 EDSAMEDKFY 730 SLDELHILDM 740 IEQGSAGKVT 750 TDYGETEKER 760 LARQRQLYKL 770 HYQCEDFKRQ 780 LRTVTFRWQE 790 NQMQIKKKDK 800 IIASLNQQVA 810 FGINKVSKLQ 820 RQIHAKDNEI 830 KNLKEQLSMK 840 RSQWEMEKHN 850 LESTMKTYVS 860 KLNAETSRAL 870 TAEVYFLQCR 880 RDFGLLHLEQ 890 TEKECLNQLA 900 RVTHMAASNL 910 ESLQLKAAVD 920 SWNAIVADVR 930 NKIAFLRTQY 940 NEQINKVKQG 950 FALSTLPPVQ 960 LPPPPPSPEI 970 LMQQFLGRPL 980 VKESFFRPIL 990 TVPQMPAVCP 1000 GVVSATGQPR 1010 APLMTGIAWA 1020 LPAPVGDAVP 1030 PSAGLRSDPS 1040 IMNWERITDR 1050 LKTAFPQQTR 1060 KELTDFLRKL 1070 KDAYGKSLSE 1080 LTFDEIVCKI 1090 SQFIDPKKSQ 1100 SQGKSVSNVN 1110 CVSPSHSPSQ 1120 PDAAQPPKPA 1130 WRPLTSQGPA 1140 TWEGASNPDE 1150 EEEEEEPCVI 1160 CHENLSPENL 1170 SVLPCAHKFH 1180 AQCIRPWLMQ 1190 QGTCPTCRLH 1200 VLLPEEFPGH PSRQLPKI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000209 protein polyubiquitination

Reference

PMID: N/A