Search Results
Overview
| Uniprot ID | Q86Y25 |
|---|---|
| Protein Name | Zinc finger protein 354C |
| Gene Name | ZNF354C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | NECGKSFKQNLHLIE |
Function
Transcriptional repressor that inhibits endothelial angiogenic sprouting (PubMed:15555547, PubMed:33154469). Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)
Protein Sequence
10
MAVDLLSAQE
20
PVTFRDVAVF
30
FSQDEWLHLD
40
SAQRALYREV
50
MLENYSSLVS
60
LGIPFSMPKL
70
IHQLQQGEDP
80
CMVEREVPSD
90
TRLGFKTWLE
100
TEALPHRQDI
110
FIEETSQGMV
120
KKESIKDGHW
130
DINFEEAVEF
140
ESEIEEEQEK
150
KPLRQMIDSH
160
EKTISEDGNH
170
TSLELGKSLF
180
TNTALVTQQS
190
VPIERIPNMY
200
YTFGKDFKQN
210
FDLMKCFQIY
220
PGGKPHICNE
230
CGKSFKQNLH
240
LIEHQRIHTG
250
EKPYKCNECE
260
KTFSHRSSLL
270
SHQRIHTGEK
280
PYKCNECEKA
290
FSNSSTLIKH
300
LRVHTGEKPY
310
RCRECGKAFS
320
QCSTLTVHQR
330
IHTGEKLYKC
340
GECEKAFNCR
350
AKLHRHQRIH
360
TGEKPYKCSE
370
CGKGYSQFTS
380
LAEHQRFHTG
390
EQLYTCLECG
400
RTFTRIVTLI
410
EHQRIHTGQK
420
PYQCNECEKA
430
FNQYSSFNEH
440
RKIHTGEKLY
450
TCEECGKAFG
460
CKSNLYRHQR
470
IHTGEKPYQC
480
NQCGKAFSQY
490
SFLTEHERIH
500
TGEKLYKCME
510
CGKAYSYRSN
520
LCRHKKVHTK
530
EKLYKWKEYG
540
KPFICSSSLT
550
QYQRFFKGDK
AYEV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0001525 | angiogenesis |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:1903671 | negative regulation of sprouting angiogenesis |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A