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Overview

Uniprot IDQ86YA3
Protein Name5'-3' DNA helicase ZGRF1
Gene NameZGRF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
113 GCQPSGLKRKFTGFQ
83 AGAIGIVKQNVNKEA

Function

5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219)

Protein Sequence

10 MESQEFIVLY 20 THQKMKKSKV 30 WQDGILKITH 40 LGNKAILYDD 50 KGACLESLFL 60 KCLEVKPGDD 70 LESDRYLITV 80 EEVKVAGAIG 90 IVKQNVNKEA 100 PELNSRTFIS 110 SGRSLGCQPS 120 GLKRKFTGFQ 130 GPRQVPKKMV 140 IMESGESAAS 150 HEAKKTGPTI 160 FSPFCSMPPL 170 FPTVGKKDVN 180 NILADPENIV 190 TYKNRERNAM 200 DFSSVFSPSF 210 QINPEVLCEE 220 NYFCSPVNSG 230 NKLSDSLLTN 240 EPVKRDSLAS 250 HYSGVSQNIR 260 SKAQILALLK 270 SESSSSCEEL 280 NSEMTEHFPQ 290 KQPQGSLKIA 300 TKPKYLIQQE 310 ECAEMKSTEN 320 LYYQHQSENT 330 MRNKSRWAMY 340 LSSQSSPIHS 350 STVDGNDTER 360 KPKAQEDDVN 370 SNLKDLSLQK 380 IIQFVETYAE 390 ERKKYNVDQS 400 VGNNDPSWNQ 410 EVKLEIPSFN 420 ESSSLQVTCS 430 SAENDGILSE 440 SDIQEDNKIP 450 FNQNDKGCIK 460 GSVLIKENAQ 470 EVNTCGTLEK 480 EYEQSESSLP 490 ELKHLQIESS 500 NNSRISDDIT 510 DMISESKMDN 520 ESLNSIHESL 530 SNVTQPFLEV 540 TFNLNNFETS 550 DTEEESQESN 560 KISQDSESWV 570 KDILVNDGNS 580 CFQKRSENTN 590 CEEIEGEHLP 600 FLTSVSDKPT 610 VTFPVKETLP 620 SQFCDKTYVG 630 FDMGICKTEN 640 TGKEIEEYSD 650 TLSNFESFKW 660 TDAVYGDNKE 670 DANKPIQEVR 680 INYDFALPPN 690 KSKGINMNLH 700 IPHIQNQIAE 710 NSNLFSEDAQ 720 PQPFILGSDL 730 DKNDEHVLPS 740 TSSSDNSVQL 750 LNTNQNHYEC 760 IALDKSNTHI 770 SNSLFYPLGK 780 KHLISKDTEA 790 HISEPEDLGK 800 IRSPPPDHVE 810 VETAREGKQY 820 WNPRNSSELS 830 GLVNTISILK 840 SLCEHSTALD 850 SLEILKKKNT 860 VFQQGTQQTY 870 EPDSPPEVRK 880 PFITVVSPKS 890 PHLHKDSQQI 900 LKEDEVELSE 910 PLQSVQFSSS 920 GSKEETAFQA 930 VIPKQIERKT 940 CDPKPVEFQG 950 HQVKGSATSG 960 VMVRGHSSQL 970 GCSQFPDSTE 980 YENFMTETPE 990 LPSTCMQIDF 1000 LQVTSPEENI 1010 STLSPVSTFS 1020 LNSRDEDFMV 1030 EFSETSLKAR 1040 TLPDDLHFLN 1050 LEGMKKSRSL 1060 ENENLQRLSL 1070 LSRTQVPLIT 1080 LPRTDGPPDL 1090 DSHSYMINSN 1100 TYESSGSPML 1110 NLCEKSAVLS 1120 FSIEPEDQNE 1130 TFFSEESREV 1140 NPGDVSLNNI 1150 STQSKWLKYQ 1160 NTSQCNVATP 1170 NRVDKRITDG 1180 FFAEAVSGMH 1190 FRDTSERQSD 1200 AVNESSLDSV 1210 HLQMIKGMLY 1220 QQRQDFSSQD 1230 SVSRKKVLSL 1240 NLKQTSKTEE 1250 IKNVLGGSTC 1260 YNYSVKDLQE 1270 ISGSELCFPS 1280 GQKIKSAYLP 1290 QRQIHIPAVF 1300 QSPAHYKQTF 1310 TSCLIEHLNI 1320 LLFGLAQNLQ 1330 KALSKVDISF 1340 YTSLKGEKLK 1350 NAENNVPSCH 1360 HSQPAKLVMV 1370 KKEGPNKGRL 1380 FYTCDGPKAD 1390 RCKFFKWLED 1400 VTPGYSTQEG 1410 ARPGMVLSDI 1420 KSIGLYLRSQ 1430 KIPLYEECQL 1440 LVRKGFDFQR 1450 KQYGKLKKFT 1460 TVNPEFYNEP 1470 KTKLYLKLSR 1480 KERSSAYSKN 1490 DLWVVSKTLD 1500 FELDTFIACS 1510 AFFGPSSINE 1520 IEILPLKGYF 1530 PSNWPTNMVV 1540 HALLVCNAST 1550 ELTTLKNIQD 1560 YFNPATLPLT 1570 QYLLTTSSPT 1580 IVSNKRVSKR 1590 KFIPPAFTNV 1600 STKFELLSLG 1610 ATLKLASELI 1620 QVHKLNKDQA 1630 TALIQIAQMM 1640 ASHESIEEVK 1650 ELQTHTFPIT 1660 IIHGVFGAGK 1670 SYLLAVVILF 1680 FVQLFEKSEA 1690 PTIGNARPWK 1700 LLISSSTNVA 1710 VDRVLLGLLS 1720 LGFENFIRVG 1730 SVRKIAKPIL 1740 PYSLHAGSEN 1750 ESEQLKELHA 1760 LMKEDLTPTE 1770 RVYVRKSIEQ 1780 HKLGTNRTLL 1790 KQVRVVGVTC 1800 AACPFPCMND 1810 LKFPVVVLDE 1820 CSQITEPASL 1830 LPIARFECEK 1840 LILVGDPKQL 1850 PPTIQGSDAA 1860 HENGLEQTLF 1870 DRLCLMGHKP 1880 ILLRTQYRCH 1890 PAISAIANDL 1900 FYKGALMNGV 1910 TEIERSPLLE 1920 WLPTLCFYNV 1930 KGLEQIERDN 1940 SFHNVAEATF 1950 TLKLIQSLIA 1960 SGIAGSMIGV 1970 ITLYKSQMYK 1980 LCHLLSAVDF 1990 HHPDIKTVQV 2000 STVDAFQGAE 2010 KEIIILSCVR 2020 TRQVGFIDSE 2030 KRMNVALTRG 2040 KRHLLIVGNL 2050 ACLRKNQLWG 2060 RVIQHCEGRE 2070 DGLQHANQYE 2080 PQLNHLLKDY 2090 FEKQVEEKQK 2100 KKSEKEKSKD KSHS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0043139 5'-3' DNA helicase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0000725 recombinational repair

Reference

PMID: N/A