Search Results

Overview

Uniprot ID	Q86YR5
Protein Name	G protein-signaling modulator 1
Gene Name	GPSM1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
454	PLPVRSRKYQEGPDA

Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction

Protein Sequence

10 MAGPAPPVAD 20 ELPGPAARRL 30 YSRMEASCLE 40 LALEGERLCK 50 AGDFKTGVAF 60 FEAAVQVGTE 70 DLKTLSAIYS 80 QLGNAYFYLK 90 EHGRALEYHK 100 HDLLLARTIG 110 DRMGEAKASG 120 NLGNTLKVLG 130 RFDEAAVCCQ 140 RHLSIAQEQG 150 DKVGEARALY 160 NIGNVYHAKG 170 KQLSWNAANA 180 TQDPGHLPPD 190 VRETLCKASE 200 FYERNLSLVK 210 ELGDRAAQGR 220 AYGNLGNTHY 230 LLGNFTEATT 240 FHKERLAIAK 250 EFGDKAAERR 260 AYSNLGNAHV 270 FLGRFDVAAE 280 YYKKTLQLSR 290 QLRDQAVEAQ 300 ACYSLGNTYT 310 LLQDYERAAE 320 YHLRHLLIAQ 330 ELADRVGEGR 340 ACWSLGNAYV 350 SMGRPAQALT 360 FAKKHLQISQ 370 EIGDRHGELT 380 ARMNVAQLQL 390 VLGRLTSPAA 400 SEKPDLAGYE 410 AQGARPKRTQ 420 RLSAETWDLL 430 RLPLEREQNG 440 DSHHSGDWRG 450 PSRDSLPLPV 460 RSRKYQEGPD 470 AERRPREGSH 480 SPLDSADVRV 490 HVPRTSIPRA 500 PSSDEECFFD 510 LLTKFQSSRM 520 DDQRCPLDDG 530 QAGAAEATAA 540 PTLEDRIAQP 550 SMTASPQTEE 560 FFDLIASSQS 570 RRLDDQRASV 580 GSLPGLRITH 590 SNAGHLRGHG 600 EPQEPGDDFF 610 NMLIKYQSSR 620 IDDQRCPPPD 630 VLPRGPTMPD 640 EDFFSLIQRV 650 QAKRMDEQRV 660 DLAGGPEQGA 670 GGPPEPQQQC QPGAS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0001965	G-protein alpha-subunit binding
Molecular Function	GO:0005092	GDP-dissociation inhibitor activity
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0000132	establishment of mitotic spindle orientation
Biological Process	GO:0034260	negative regulation of GTPase activity
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0016239	positive regulation of macroautophagy

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.