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Overview

Uniprot IDQ86YU9
Protein NamePhosphoinositide phospholipase C
Gene NameFLJ00414
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
875 GTRDTGSKGVADDVV

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain

Protein Sequence

10 PVLPPHPAVS 20 IDSIQEVSEG 30 RQSEVFQRYP 40 DGSFDPNCCF 50 SIYHGSHRES 60 LDLVSTSSEV 70 ARTWVTGLRY 80 LMAGISDEDS 90 LARRQRTRDQ 100 WLKQTFDEAD 110 KNGDGSLSIG 120 EVLQLLHKLN 130 VNLPRQRVKQ 140 MFREADTDDH 150 QGTLGFEEFC 160 AFYKMMSTRR 170 DLYLLMLTYS 180 NHKDHLDAAS 190 LQRFLQVEQK 200 MAGVTLESCQ 210 DIIEQFEPCP 220 ENKSKGLLGI 230 DGFTNYTRSP 240 AGDIFNPEHH 250 HVHQDMTQPL 260 SHYFITSSHN 270 TYLVGDQLMS 280 QSRVDMYAWV 290 LQAGCRCVEV 300 DCWDGPDGEP 310 IVHHGYTLTS 320 KILFKDVIET 330 INKYAFIKNE 340 YPVILSIENH 350 CSVIQQKKMA 360 QYLTDILGDK 370 LDLSSVSSED 380 ATTLPSPQML 390 KGKILVKGKK 400 LPANISEDAE 410 EGEVSDEDSA 420 DEIDDDCKLL 430 NGDASTNRKR 440 VENTAKRKLD 450 SLIKESKIRD 460 CEDPNNFSVS 470 TLSPSGKLGR 480 KSKAEEDVES 490 GEDAGASRRN 500 GRLVVGSFSR 510 RKKKGSKLKK 520 AASVEEGDEG 530 QDSPGGQSRG 540 ATRQKKTMKL 550 SRALSDLVKY 560 TKSVATHDIE 570 MEAASSWQVS 580 SFSETKAHQI 590 LQQKPAQYLR 600 FNQQQLSRIY 610 PSSYRVDSSN 620 YNPQPFWNAG 630 CQMVALNYQS 640 EGRMLQLNRA 650 KFSANGGCGY 660 VLKPGCMCQG 670 VFNPNSEDPL 680 PGQLKKQLVL 690 RIISGQQLPK 700 PRDSMLGDRG 710 EIIDPFVEVE 720 IIGLPVDCSR 730 EQTRVVDDNG 740 FNPTWEETLV 750 FMVHMPEIAL 760 VRFLVWDHDP 770 IGRDFIGQRT 780 LAFSSMMPGY 790 RHVYLEGMEE 800 ASIFVHVAVS 810 DISGKVKQVL 820 GLKGLFLRGP 830 KPGSLDSHAA 840 GRPPARPSVS 850 QRILRRTASA 860 PTKSQKPGRR 870 GFPELVLGTR 880 DTGSKGVADD 890 VVPPGPGPAP 900 EAPAQEGPGS 910 GSPRGKAPAA 920 VAEKSPVRVR 930 PLRVLDGPGP 940 AGMAATCMKC 950 VVGSCAGVNT 960 GGLQRERPPS 970 PGPASRQAAI 980 RQQPRARADS 990 LGAPCCGLDP 1000 HAIPGRSREA 1010 PKGPGAWRQG 1020 PGGSGSMSSD 1030 SSSPDSPGIP 1040 ERSPRWPEGA 1050 CRQPGALQGE 1060 MSALFAQKLE 1070 EIRSKSPMFS 1080 AGKPLLPCVV 1090 LPHAPGMAGP 1100 GSPAAASAWT 1110 VSPRVLVLVA 1120 LYPWHCLRGT LLPWLACGP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0016042 lipid catabolic process

Reference

PMID: N/A