Search Results

Overview

Uniprot IDQ8BFR5
Protein NameElongation factor Tu, mitochondrial
Gene NameTufm
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
234 RDPELGVKSVQKLLD
286 LERGILKKGDECELL
297 CELLGHNKNIRTVVT
55 KKTYVRDKPHVNVGT
88 LAEGGGAKFKKYEEI
91 GGGAKFKKYEEIDNA

Function

GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy (By similarity)

Protein Sequence

10 MAAATLLRAT 20 PRFSGLCASP 30 TPFLQGRLRP 40 LKAPASPFLC 50 RGLAVEAKKT 60 YVRDKPHVNV 70 GTIGHVDHGK 80 TTLTAAITKI 90 LAEGGGAKFK 100 KYEEIDNAPE 110 ERARGITINA 120 AHVEYSTAAR 130 HYAHTDCPGH 140 ADYVKNMITG 150 TAPLDGCILV 160 VAANDGPMPQ 170 TREHLLLAKQ 180 IGVEHVVVYV 190 NKADAVQDSE 200 MVELVELEIR 210 ELLTEFGYKG 220 EETPVIVGSA 230 LCALEQRDPE 240 LGVKSVQKLL 250 DAVDTYIPVP 260 TRDLDKPFLL 270 PVESVYSIPG 280 RGTVVTGTLE 290 RGILKKGDEC 300 ELLGHNKNIR 310 TVVTGIEMFH 320 KSLERAEAGD 330 NLGALVRGLK 340 REDLRRGLVM 350 VKPGSIQPHQ 360 KVEAQVYILS 370 KEEGGRHKPF 380 VSHFMPVMFS 390 LTWDMACRVI 400 LPPGKELAMP 410 GEDLKLSLIL 420 RQPMILEKGQ 430 RFTLRDGNKT 440 IGTGLVTDVP 450 AMTEEDKNIK WS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0045202 synapse
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:1902775 mitochondrial large ribosomal subunit assembly
Biological Process GO:0032543 mitochondrial translation
Biological Process GO:0070125 mitochondrial translational elongation
Biological Process GO:0006414 translational elongation

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.