Search Results
Overview
| Uniprot ID | Q8BGC4 |
|---|---|
| Protein Name | Prostaglandin reductase-3 |
| Gene Name | Ptgr3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 197 | VQLSKIAKCHVIGTC |
| 35 | AIPRTMQKLVVTRLS |
Function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation
Protein Sequence
10
MLRLAAAGAR
20
AIVDMSYARH
30
FLDFQGSAIP
40
RTMQKLVVTR
50
LSPNFHEAVT
60
LRRDCPVPLP
70
GDGDLLVRNR
80
FVGINASDIN
90
YSAGRYDPSL
100
KPPFDIGFEG
110
IGEVVALGLS
120
ASARYTVGQA
130
VAYMAPGSFA
140
EYTVVPASIA
150
IPMPSVKPEY
160
LTMLVSGTTA
170
YLSLEELGEL
180
SEGKKVLVTA
190
AAGGTGQFAV
200
QLSKIAKCHV
210
IGTCSSDEKA
220
AFLKSIGCDR
230
PINYRTEPVE
240
TVLKQEYPEG
250
VDVVYESVGG
260
AMFDLAVDAL
270
ATKGRLIVIG
280
FISGYQSPTG
290
LSPIKAGVLP
300
TKLLKKSASL
310
RGFFLNHYFS
320
KYQAAMERLL
330
ELYARGDLVC
340
EVDLGHLAPD
350
GRFIGLESVF
360
QAVDYMYTGK
370
NTGKLVVELP
HPVSSKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0047522 | 15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.