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Overview

Uniprot ID	Q8BGP6
Protein Name	Mitochondrial glutathione transporter SLC25A40
Gene Name	Slc25a40
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
53	AQNNPFPKGKCFLYS

Function

Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288)

Protein Sequence

10 MEPETEGPPP 20 TIPVTPLQQM 30 IASCTGAVLT 40 SLMVTPLDVV 50 KIRLQAQNNP 60 FPKGKCFLYS 70 NGLMDHMCVC 80 EEESKKAWYK 90 KPGNFRGTLD 100 AFLKILRNEG 110 IKSLWSGLPP 120 TLVMAIPATV 130 IYFTCYEQLS 140 AFLKTKLGEN 150 ETRIPIVAGV 160 VARFGAVTVI 170 SPLELIRTKV 180 QSKKFSYKEL 190 YQFVSMRVSE 200 DGWISLWKGW 210 APTILRDVPF 220 SAMYWYNYEN 230 LKRWLCEKSG 240 LYEPTFMINF 250 TSGALSGSFA 260 AVATLPFDVV 270 KTQKQTQLWT 280 NEYCKFPAPL 290 DMSTWTIMKN 300 IVADKGFSGL 310 FTGLIPRLVK 320 IVPACAIMIS 330 SYELGKSFFQ KQNVESR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0034634	glutathione transmembrane transporter activity
Biological Process	GO:0048821	erythrocyte development
Biological Process	GO:1990542	mitochondrial transmembrane transport

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.