Search Results

Overview

Uniprot ID	Q8BGY7
Protein Name	Mitochondrial inner membrane scaffold 1
Gene Name	Mims1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
110	QETPSEKKEETDPLQ
247	TKELITEKMEETKDR
258	TKDRLTEKLQETKGK

Function

Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism (PubMed:29618611, PubMed:37522353). Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes (PubMed:37522353). Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis (PubMed:29618611, PubMed:31980842). In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing (PubMed:37816711). Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function (PubMed:37522353). In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors (PubMed:31980842)

Protein Sequence

10 MQWNVPRTMS 20 RLALRTFVEA 30 QKARLFDHHW 40 RIKGPLLVHR 50 GEYRVAWTPH 60 LRKQWLHLSA 70 VQCLAKQRNL 80 LDAQPPQLGT 90 LRQERWEQDI 100 LSKRVLSSSS 110 TSQETPSEKK 120 EETDPLQDKS 130 ISLYQRFKKT 140 FRQYGKVLIP 150 VHLITSGIWF 160 GTFYYATIKG 170 VNVIPFLEVI 180 GLPDSIVDIL 190 KNSQSGNALT 200 AYAMFKIATP 210 ARYTVTLGGT 220 SFTVKYLRSH 230 GYMSTPPPVK 240 EYLQGRMEET 250 KELITEKMEE 260 TKDRLTEKLQ 270 ETKGKVSFKK KVE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.