Search Results

Overview

Uniprot ID	Q8BH59
Protein Name	Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
Gene Name	Slc25a12
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
377	KNSFDCFKKVLRYEG
406	VAPEKAIKLTVNDFV
661	GLYLPKFKSPSVAVA

Function

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (By similarity)

Protein Sequence

10 MAVKVHTTKR 20 GDPHELRNIF 30 LQYASTEVDG 40 EHYMTPEDFV 50 QRYLGLYNDP 60 NSNPKIVQLL 70 AGVADQTKDG 80 LISYQEFLAF 90 ESVLCAPDSM 100 FIVAFQLFDK 110 SGNGEVTFEN 120 VKEIFGQTII 130 HHHIPFNWDC 140 EFIRLHFGHN 150 RKKHLNYVEF 160 TQFLQELQLE 170 HARQAFALKD 180 KSKSGMISGL 190 DFSDVMVTIR 200 SHMLTPFVEE 210 NLVSAAGGGT 220 SHQVSFSYFN 230 AFNSLLNNME 240 LVRKIYSTLA 250 GTRKDIEVTK 260 EEFAQSAIRY 270 GQVTPLEIDI 280 LYQLADLYNA 290 SGRLTLADIE 300 RIAPLAEGAL 310 PYNLAELQRQ 320 QSPGLGRPIW 330 LQIAESAYRF 340 TLGSVAGAVG 350 ATAVYPIDLV 360 KTRMQNQRGT 370 GSVVGELMYK 380 NSFDCFKKVL 390 RYEGFFGLYR 400 GLIPQLIGVA 410 PEKAIKLTVN 420 DFVRDKFTKR 430 DGSIPLPAEI 440 LAGGCAGGSQ 450 VIFTNPLEIV 460 KIRLQVAGEI 470 TTGPRVSALN 480 VLQDLGLFGL 490 YKGAKACFLR 500 DIPFSAIYFP 510 VYAHCKLLLA 520 DENGRVGGIN 530 LLTAGALAGV 540 PAASLVTPAD 550 VIKTRLQVAA 560 RAGQTTYSGV 570 VDCFRKILRE 580 EGPSAFWKGT 590 AARVFRSSPQ 600 FGVTLVTYEL 610 LQRWFYIDFG 620 GLKPSGSEPT 630 PKSRIADLPP 640 ANPDHIGGYR 650 LATATFAGIE 660 NKFGLYLPKF 670 KSPSVAVAQP KAAAAAQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043209	myelin sheath
Molecular Function	GO:0000514	3-sulfino-L-alanine: proton, glutamate antiporter activity
Molecular Function	GO:0015172	acidic amino acid transmembrane transporter activity
Molecular Function	GO:0000515	aspartate:glutamate, proton antiporter activity
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0015183	L-aspartate transmembrane transporter activity
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity
Biological Process	GO:0015810	aspartate transmembrane transport
Biological Process	GO:0006537	glutamate biosynthetic process
Biological Process	GO:0015813	L-glutamate transmembrane transport
Biological Process	GO:0043490	malate-aspartate shuttle
Biological Process	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process
Biological Process	GO:0010907	positive regulation of glucose metabolic process
Biological Process	GO:0031643	positive regulation of myelination
Biological Process	GO:0051592	response to calcium ion

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.