Search Results

Overview

Uniprot IDQ8BIJ6
Protein NameIsoleucine--tRNA ligase, mitochondrial
Gene NameIars2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
241 GLVYRSYKPVYWSPS
437 LQNKAVLKEGTDVVI
451 IKMLQATKNVLKEEN
683 DTIISGGKDHSKEPP
687 SGGKDHSKEPPYGAD
781 YKQYDFGKVVRLLKA

Function

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile))

Protein Sequence

10 MHWGLCPRGP 20 GAAAVAAAGS 30 FWGPARLPSR 40 LGCLGMTRRL 50 VVRSVAGADS 60 PQSSSKGGRY 70 RDTVLLPQTS 80 FPMKLLGRQQ 90 SDMELEIQQK 100 CGFSELYSWQ 110 RERKVKTEFC 120 LHDGPPYANG 130 DPHVGHALNK 140 ILKDIANRFH 150 MMRGSKVHFV 160 PGWDCHGLPI 170 ETKVLSELGV 180 DAQSLSAMEI 190 REKARSFAQA 200 AIEKQKSAFV 210 RWGVMADWNN 220 CYYTFDPKYE 230 AKQLRVFYQM 240 YEKGLVYRSY 250 KPVYWSPSSR 260 TALAEAELEY 270 NPEHVSRSIY 280 VRFPLLRPPP 290 KLESLTDASS 300 PVSVLVWTTQ 310 PWTIPANQAI 320 CYMPEAKYAV 330 VKCSASGHLY 340 ILAEDKIAPV 350 ASALETTFDV 360 VAAFSGVDLE 370 GGTCSHPLTP 380 DKVSPLLPAT 390 HVTMAKGTGL 400 VHTAPAHGME 410 DYSVASQHSL 420 PMDCLVDEGG 430 MFTDAAGPEL 440 QNKAVLKEGT 450 DVVIKMLQAT 460 KNVLKEENIV 470 HSYPCDWRTK 480 TPVLIRASKQ 490 WFVNITDIKA 500 AAKESLKTVK 510 FIPGAALNSM 520 TDMLDRRPYW 530 CISRQRVWGV 540 PIPVFHHKTK 550 DEYLINSQTT 560 EHIIKLVEQH 570 GSDVWWTLPA 580 EQLLPAEVLA 590 QAGGPGALEY 600 APGQDILDIW 610 FDSGTSWSCV 620 LQDTQQRADL 630 YLEGKDQLGG 640 WFQSSLLTSV 650 ATRSKAPFRT 660 VMVHGFTLGE 670 KGEKMSKSLG 680 NVINPDTIIS 690 GGKDHSKEPP 700 YGADILRWWI 710 AESNVFTEVT 720 IGPSVLSAAR 730 DDISKLRNTL 740 RFLLGNLTGF 750 NPETDSVPVK 760 NMYVIDQYML 770 HLIQDFATKI 780 TDSYKQYDFG 790 KVVRLLKAFY 800 TRELSSFYFS 810 IVKDRLYCEN 820 EKDPKRRSCQ 830 TALAEILDVL 840 VRAFAPILPH 850 LAEEVFQHIP 860 YVTEPKSVFR 870 TGWINTSSIW 880 KKPGLEEAVE 890 SACAMRDSFL 900 GSIPGKNAAE 910 YEVIIVIEPG 920 LLFEIMEMLQ 930 AEETSSTSQL 940 NELMMASQTT 950 LLAQEPRERT 960 AGDIELTGTF 970 VINLEGGDIR 980 EESSYKVIVV 990 PTAREKCPRC 1000 WKHTSETADA 1010 LCPRCAEVIG AK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004822 isoleucine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006428 isoleucyl-tRNA aminoacylation
Biological Process GO:0032543 mitochondrial translation

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.