Overview
| Uniprot ID | Q8BK67 |
|---|
| Protein Name | Protein RCC2 |
|---|
| Gene Name | Rcc2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 75 |
ARPATAGKAAGAAAI |
Function
Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as a guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity)
Protein Sequence
10
MPRKKGAAWE
20
EPSSGNGTAR
30
AGPRRRGGPA
40
GRKRERPERC
50
SSSSGGGSSG
60
DEDGPELDGA
70
PGGGKRTARP
80
ATAGKAAGAA
90
AIITEPEHTK
100
ERVKLEGSKC
110
KGQLLIFGAT
120
NWDLIGRKEV
130
PKQQAAYRNL
140
GQNLWGPHRY
150
GCLSGVRVRT
160
VVSGSCAAHS
170
LLITTEGKLW
180
SWGRNEKGQL
190
GHGDTKRVEA
200
PRLIEALSHE
210
AIVLAACGRN
220
HTLALTDTGS
230
VFAFGENKMG
240
QLGLGNQTDA
250
VPSPAQIMYN
260
GQPITKMACG
270
AEFSMLMDCK
280
GNLYSFGCPE
290
YGQLGHNSDG
300
KFIARAQRIE
310
YDCELVPRRV
320
AIFIEKTKDG
330
QILPVPNVVV
340
RDVACGANHT
350
LVLDSQKRVF
360
SWGFGGYGRL
370
GHAEQKDEMV
380
PRLVKLFDFP
390
GRGATQIYAG
400
YTCSFAVSEV
410
GGLFFWGATN
420
TSRESTMYPK
430
AVQDLCGWRI
440
RSLACGKSSI
450
IVAADESTIS
460
WGPSPTFGEL
470
GYGDHKPKSS
480
TAAQEVKTLD
490
GIFSEQVAMG
500
YSHSLVIARD
510
ESEAEKEKLQ
520
RLPEYTPRTL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034506 |
chromosome, centromeric core domain |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:1990023 |
mitotic spindle midzone |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0090630 |
activation of GTPase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0072356 |
chromosome passenger complex localization to kinetochore |
| Biological Process |
GO:0045184 |
establishment of protein localization |
| Biological Process |
GO:0048041 |
focal adhesion assembly |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:0051895 |
negative regulation of focal adhesion assembly |
| Biological Process |
GO:0034260 |
negative regulation of GTPase activity |
| Biological Process |
GO:1900025 |
negative regulation of substrate adhesion-dependent cell spreading |
| Biological Process |
GO:0051987 |
positive regulation of attachment of spindle microtubules to kinetochore |
| Biological Process |
GO:0010971 |
positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0030334 |
regulation of cell migration |
| Biological Process |
GO:0010762 |
regulation of fibroblast migration |
| Biological Process |
GO:1900027 |
regulation of ruffle assembly |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.