Search Results
Overview
| Uniprot ID | Q8BKZ9 |
|---|---|
| Protein Name | Pyruvate dehydrogenase protein X component, mitochondrial |
| Gene Name | Pdhx |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 218 | FTKEDALKLVELKQM |
| 223 | ALKLVELKQMGKITE |
| 227 | VELKQMGKITESRPA |
Function
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity)
Protein Sequence
10
MAASWRLHCN
20
QPLLRYLLGF
30
SSRRSLGLAQ
40
GAAAWPVDRG
50
ASWRWFHSTQ
60
LLQADPIKVL
70
MPSLSPTMEQ
80
GNIVKWLRKE
90
GEAVSAGDSL
100
CEIETDKAVV
110
TLDANDDGIL
120
AKIVVEEGAK
130
NIQLGSLIAL
140
MVEEGEDWKQ
150
VEIPKDVSAP
160
PPVSKPPAPT
170
QPSPQPQIPC
180
PARKEHKGTA
190
RFRLSPAARN
200
ILEKHSLDAS
210
QGTATGPRGI
220
FTKEDALKLV
230
ELKQMGKITE
240
SRPASAPPPS
250
LSASVPPQAT
260
AGPSYPRPMT
270
PPVSIPGQPN
280
AAGTFTEIPA
290
SNIRRVIAKR
300
LTESKSTVPH
310
AYATADCDLG
320
AVLKVRRDLV
330
KDDIKVSVND
340
FIIRAAAVTL
350
KQMPGVNVTW
360
DGEGPKQLPS
370
VDISVAVATD
380
KGLITPIIKD
390
AAAKGIQEIA
400
DSVKVLSKKA
410
RDGKLMPEEY
420
QGGSFSISNL
430
GMFGIDEFAA
440
VINPPQACIL
450
AVGRFRPVLK
460
LTEDEEGNPQ
470
LQQHQLITVT
480
MSSDSRVVDD
490
ELATRFLETF
500
KANLENPMRL
G
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045254 | pyruvate dehydrogenase complex |
| Molecular Function | GO:0004742 | dihydrolipoyllysine-residue acetyltransferase activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.