Search Results

Overview

Uniprot IDQ8BMF3
Protein NameNADP-dependent malic enzyme, mitochondrial
Gene NameMe3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
454 KAECTAEKCYRVTEG
558 KVLDYAYKHNLASYY
569 ASYYPEPKDKEAFVK

Function

Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (By similarity). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity)

Protein Sequence

10 MGAALGTGAR 20 LTSVPRIACS 30 SLRRQAPSAP 40 AQGCHSKSGP 50 PRPVPLKKRG 60 YDVTRNPHLN 70 KGMAFTLEER 80 LQLGIHGLIP 90 PCFLSQDVQL 100 LRIMRYYENQ 110 QSDLDKYIIL 120 MTLQDRNEKL 130 FYRVLTSDVE 140 KFMPIVYTPT 150 VGLACQHYGL 160 TFRRPRGLFI 170 TIHDKGHIAT 180 MLNSWPEDNI 190 KAVVVTDGER 200 ILGLGDLGCY 210 GMGIPVGKLA 220 LYTACGGVNP 230 QQCLPVLLDV 240 GTNNEELLRD 250 PLYIGLKHQR 260 VRGEEYDDLL 270 DEFMQAVTDK 280 FGINCLIQFE 290 DFANANAFRL 300 LNKYRNKYCM 310 FNDDIQGTAS 320 VAVAGILAAL 330 RITKNRLSNH 340 VFVFQGAGEA 350 AMGIAHLLVM 360 ALEKEGIPKT 370 EAIKKIWMVD 380 SKGLIVKGRS 390 HLNHEKEMFA 400 QDHPEVNSLE 410 EVVRLVKPTA 420 IIGVAAIAGA 430 FTEQILRDMA 440 SFHERPIVFA 450 LSNPTSKAEC 460 TAEKCYRVTE 470 GRGIFASGSP 480 FKSVTLEDGR 490 TFTPGQGNNA 500 YVFPGVALGV 510 IAGGIRHIPD 520 EIFLLTAEQI 530 AQEVSEQHLS 540 QGRLYPPLST 550 IRDVSLRIAV 560 KVLDYAYKHN 570 LASYYPEPKD 580 KEAFVKSLIY 590 TPDYDSFSLD 600 TYSWPKEAMS VQKV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Function GO:0004470 malic enzyme activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0070401 NADP+ binding
Molecular Function GO:0008948 oxaloacetate decarboxylase activity
Biological Process GO:0006108 malate metabolic process
Biological Process GO:0042866 pyruvate biosynthetic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.