Search Results

Overview

Uniprot ID	Q8BMF4
Protein Name	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Gene Name	Dlat
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
363	AKKLAAEKGIDLTQV
371	GIDLTQVKGTGPEGR
382	PEGRIIKKDIDSFVP
461	LVRKELNKMLEGKGK
468	KMLEGKGKISVNDFI

Function

The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation

Protein Sequence

10 MWRVCARRAR 20 SAVPRDGFRA 30 RWAALKEGPG 40 APCGSPRIGP 50 AAVRCGSGIP 60 RYGVRSLCGW 70 SSGSGTVPRN 80 RLLRQLLGSP 90 SRRSYSLPPH 100 QKVPLPSLSP 110 TMQAGTIARW 120 EKKEGEKISE 130 GDLIAEVETD 140 KATVGFESLE 150 ECYMAKILVP 160 EGTRDVPVGS 170 IICITVEKPQ 180 DIEAFKNYTL 190 DLAAAAAPQA 200 APAAAPAPAA 210 APAAPSASAP 220 GSSYPTHMQI 230 VLPALSPTMT 240 MGTVQRWEKK 250 VGEKLSEGDL 260 LAEIETDKAT 270 IGFEVQEEGY 280 LAKILVPEGT 290 RDVPLGAPLC 300 IIVEKQEDIA 310 AFADYRPTEV 320 TSLKPQAAPP 330 APPPVAAVPP 340 TPQPVAPTPS 350 AAPAGPKGRV 360 FVSPLAKKLA 370 AEKGIDLTQV 380 KGTGPEGRII 390 KKDIDSFVPS 400 KAAPAAAAAM 410 APPGPRVAPA 420 PAGVFTDIPI 430 SNIRRVIAQR 440 LMQSKQTIPH 450 YYLSVDVNMG 460 EVLLVRKELN 470 KMLEGKGKIS 480 VNDFIIKASA 490 LACLKVPEAN 500 SSWMDTVIRQ 510 NHVVDVSVAV 520 STPAGLITPI 530 VFNAHIKGLE 540 TIASDVVSLA 550 SKAREGKLQP 560 HEFQGGTFTI 570 SNLGMFGIKN 580 FSAIINPPQA 590 CILAIGASED 600 KLIPADNEKG 610 FDVASVMSVT 620 LSCDHRVVDG 630 AVGAQWLAEF 640 KKYLEKPITM LL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0045254	pyruvate dehydrogenase complex
Cellular Component	GO:0120212	sperm head-tail coupling apparatus
Molecular Function	GO:0016407	acetyltransferase activity
Molecular Function	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0006006	glucose metabolic process
Biological Process	GO:0042867	pyruvate catabolic process
Biological Process	GO:0006086	pyruvate decarboxylation to acetyl-CoA
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.