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Overview

Uniprot IDQ8BMS4
Protein NameUbiquinone biosynthesis O-methyltransferase, mitochondrial
Gene NameCoq3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
144 SASHHPGKPLSGMKI
197 SFDPVLDKRIQYKVC

Function

O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10

Protein Sequence

10 MWRGGRLGSR 20 GVRLLETLGF 30 GCPSAVAQPP 40 RLTSRSAYSG 50 TQLTRNLQIK 60 PWELGEHGTM 70 CFRSYRMALS 80 CLSRVKTYRT 90 PWKRLYSTSQ 100 TTVDSREVKN 110 FQALAHTWWD 120 EYGKFAPLHS 130 MNDLRVPFIR 140 DNLLKTSASH 150 HPGKPLSGMK 160 ILDVGCGGGL 170 LTEPLGRLGA 180 SVVGIDPVAE 190 NIKIAQHHKS 200 FDPVLDKRIQ 210 YKVCSLEEAV 220 DESAECFDAV 230 VASEVVEHVS 240 HLEMFIQCCY 250 QVLKPGGSLF 260 ITTVNKTQLS 270 YALGIVFAEQ 280 IAGIVPKGTH 290 TWEKFVSPEK 300 LESILEPNGL 310 SVETVAGLVY 320 NPFSGYWHWS 330 ENTSLNYAAH 340 AVRSRAQEHQ 350 EPAESALKGE 360 TGALHANTSG 370 SPSVREEQRT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031314 extrinsic component of mitochondrial inner membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0110142 ubiquinone biosynthesis complex
Molecular Function GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity
Molecular Function GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008171 O-methyltransferase activity
Molecular Function GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity
Biological Process GO:0006071 glycerol metabolic process
Biological Process GO:0032259 methylation
Biological Process GO:0006744 ubiquinone biosynthetic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.