Search Results

Overview

Uniprot ID	Q8BW75
Protein Name	Amine oxidase [flavin-containing] B
Gene Name	Maob
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
52	TIRNKNVKYVDLGGS
93	ERLIHFVKGKSYAFR

Function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:4156831). Preferentially degrades benzylamine and phenylethylamine (By similarity)

Protein Sequence

10 MSNKSDVIVV 20 GGGISGMAAA 30 KLLHDCGLSV 40 VVLEARDRVG 50 GRTYTIRNKN 60 VKYVDLGGSY 70 VGPTQNRILR 80 LAKELGLETY 90 KVNEVERLIH 100 FVKGKSYAFR 110 GPFPPVWNPI 120 TYLDNNNLWR 130 TMDEMGQEIP 140 SDAPWKAPLA 150 EEWDYMTMKE 160 LLDKICWTKS 170 TKQIATLFVN 180 LCVTAETHEV 190 SALWFLWYVK 200 QCGGTTRIIS 210 TTNGGQERKF 220 IGGSGQVSER 230 IKDILGDRVK 240 LERPVIHIDQ 250 TGENVIVKTL 260 NHEIYEAKYV 270 ISAIPPALGM 280 KIHYSPPLPM 290 LRNQLISRVP 300 LGSVIKCMVY 310 YKEPFWRKKD 320 FCGTMVIEGE 330 EAPIAYTLDD 340 TKPDGTYAAI 350 MGFILAHKAR 360 KLVRLTKEER 370 LRKLCELYAK 380 VLNSQEALQP 390 VHYEEKNWCE 400 EQYSGGCYTT 410 YFPPGILTQY 420 GRVLRQPVGK 430 IFFAGTETAS 440 HWSGYMEGAV 450 EAGERAAREI 460 LHAIGKIPED 470 EIWQPEPESL 480 DVPARPITST 490 FLERHLPSVP 500 GLLKLFGLTT 510 ILSATALGFL 520 AHKRGLFVHF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043025	neuronal cell body
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0097621	monoamine oxidase activity
Molecular Function	GO:0008131	primary methylamine oxidase activity
Biological Process	GO:0014063	negative regulation of serotonin secretion
Biological Process	GO:0019607	phenylethylamine catabolic process
Biological Process	GO:0045964	positive regulation of dopamine metabolic process
Biological Process	GO:0048545	response to steroid hormone
Biological Process	GO:0042428	serotonin metabolic process
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005741	mitochondrial outer membrane

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.