Search Results
Overview
| Uniprot ID | Q8BWF0 |
|---|---|
| Protein Name | Succinate-semialdehyde dehydrogenase, mitochondrial |
| Gene Name | Aldh5a1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 253 | PCSRNKAKEVGEVLC |
| 353 | TKFAEAMKKSLRVGN |
| 382 | KAVEKVEKQVNDAVA |
| 399 | ATVVTGGKRHQSGGN |
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
Protein Sequence
10
MATCFLLRSF
20
WAARPALPPP
30
GRFRPEPAGT
40
PRRSYASGPG
50
GLHADLLRGD
60
SFVGGRWLPA
70
PATFPVYDPA
80
SGAKLGTVAD
90
CGVPEARAAV
100
RAAYDAFNSW
110
KGVSVKERSL
120
LLRKWYDLMI
130
QNKDDLAKII
140
TAESGKPLKE
150
AQGEILYSAL
160
FLEWFSEEAR
170
RIYGDIIYTS
180
AKDKRGLVLK
190
QPVGVAAIIT
200
PWNFPSAMIT
210
RKVGAALAAG
220
CTVVVKPAED
230
TPYSALALAQ
240
LANQAGIPAG
250
VYNVIPCSRN
260
KAKEVGEVLC
270
TDPLVSKISF
280
TGSTATGKIL
290
LHHAANSVKR
300
VSMELGGLAP
310
FIVFDSANVD
320
QAVAGAMASK
330
FRNAGQTCVC
340
SNRFLVQRGI
350
HDSFVTKFAE
360
AMKKSLRVGN
370
GFEEGTTQGP
380
LINEKAVEKV
390
EKQVNDAVAK
400
GATVVTGGKR
410
HQSGGNFFEP
420
TLLSNVTRDM
430
LCITEETFGP
440
LAPVIKFDKE
450
EEAVAIANAA
460
EVGLAGYFYS
470
QDPAQIWRVA
480
EQLEVGMVGV
490
NEGLISSVEC
500
PFGGVKQSGL
510
GREGSKYGID
520
EYLEVKYVCY
GGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0031406 | carboxylic acid binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0009450 | gamma-aminobutyric acid catabolic process |
| Biological Process | GO:0009448 | gamma-aminobutyric acid metabolic process |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0009791 | post-embryonic development |
| Biological Process | GO:0006105 | succinate metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.