Overview
| Uniprot ID | Q8BWM0 |
|---|
| Protein Name | Prostaglandin E synthase 2 |
|---|
| Gene Name | Ptges2 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 383 |
HHVNPSCKD****** |
Function
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear (PubMed:12050152)
Protein Sequence
10
MAQAARLSWV
20
LVSSRCALTE
30
GLLTRPWQPL
40
SAQSRAGFTR
50
VAAGSRGAAV
60
RKGSPRLLGA
70
AALALGGALG
80
LYHTVRWHQR
90
SQDLRAERSA
100
AQLPLSNSLQ
110
LTLYQYKTCP
120
FCSKVRAFLD
130
FHSLPYQVVE
140
VNPVRRTEIK
150
FSSYRKVPIL
160
VAQEGDSLQQ
170
LNDSSVIISA
180
LKTYLVSGQP
190
LEEVITYYPP
200
MKAMNDQGKE
210
VTEFCNKYWL
220
MLDEKEAQQM
230
YGGKEARTEE
240
MKWRQWADDW
250
LVHLISPNVY
260
RTPAEALASF
270
DYIVREGKFG
280
AVEAAMAKYV
290
GAAAMYLISK
300
RLKSRHHLQD
310
DVRVDLYEAA
320
NKWVTAVGKD
330
RPFMGGQKPN
340
LADLAVYGVL
350
RVMEGLEAFD
360
DLMRHSHIQP
370
WYLRMERAIE
380
EAPSVHHVNP
SCKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0050220 |
prostaglandin-E synthase activity |
| Biological Process |
GO:0019371 |
cyclooxygenase pathway |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0046903 |
secretion |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0036134 |
12-hydroxyheptadecatrienoic acid synthase activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0043295 |
glutathione binding |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0016829 |
lyase activity |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.