Search Results
Overview
| Uniprot ID | Q8BYL4 |
|---|---|
| Protein Name | Tyrosine--tRNA ligase, mitochondrial |
| Gene Name | Yars2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 362 | QEGLDSAKRCTQALY |
Function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)
Protein Sequence
10
MAAPMLRRLC
20
RVPQSLVWLR
30
GSRAVRPGAR
40
GMLVAPRARG
50
LFKEFFPESG
60
TKTELPELFD
70
RRRAGSSPQT
80
VYCGFDPTGD
90
SLHVGHLLTL
100
LGLFHFQRAG
110
HNVIALVGGS
120
TALLGDPSGR
130
TKGREALSAE
140
CVRANAHALR
150
RGLEALAANH
160
ARLFADGRPW
170
GSFTVLDNAA
180
WFQEQHLVDF
190
LATVGGHFRM
200
GTLLSRLSVQ
210
SRLKSPEGMS
220
LAEFFYQVLQ
230
AYDFYYLFQH
240
YGCRVQLGGS
250
DQLGNIMSGY
260
EFIHKLTGED
270
VFGITVPLIT
280
STTGAKLGKS
290
AGNAVWLNRE
300
KTSPFELYQF
310
FVRQQDDSVE
320
RYLKLFTFLP
330
LPEIDHIMQL
340
HVKEPEKRVA
350
QKRLAAEVTK
360
LVHGQEGLDS
370
AKRCTQALYH
380
SSIEALEVMS
390
DQELKELFKE
400
ASFSELVLDP
410
GTSVIDTCRK
420
ANAIPDGPRG
430
YRMITEGGVS
440
INHRQVTNPE
450
SVLVIGQHIL
460
KNGLSLLKIG
470
KRNFYIIKWL
QL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016604 | nuclear body |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0072545 | L-tyrosine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0004831 | tyrosine-tRNA ligase activity |
| Biological Process | GO:0070184 | mitochondrial tyrosyl-tRNA aminoacylation |
| Biological Process | GO:0043039 | tRNA aminoacylation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.