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Overview

Uniprot ID	Q8BYM8
Protein Name	Probable cysteine--tRNA ligase, mitochondrial
Gene Name	Cars2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
308	EKMSKSLKNYITIKD

Function

Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)

Protein Sequence

10 MLRARGPGPG 20 ALLLRAALGL 30 GRRGRSWQRP 40 QGQDTGVQVH 50 NSLTGRKEPL 60 IVARSDAVSW 70 YSCGPTVYDH 80 AHLGHACSYV 90 RFDIIRRILT 100 RVFGCNVVMA 110 MSITDVDDKI 120 IKRANEMNVT 130 PASLASLFEE 140 EFKQDMAALK 150 VLPPTVYLRV 160 TENIPQIIAF 170 IEGIIAHGHA 180 YSTATGSVYF 190 DLHARGDKYG 200 KLVNTVPSAT 210 AEPGDSDKRH 220 SSDFALWKAA 230 KPQEVFWASP 240 WGDGRPGWHI 250 ECSTMASEVF 260 GSHLDIHTGG 270 IDLAFPHHEN 280 EIAQSEVFHQ 290 CQQWGNYFLH 300 SGHLHVKGTE 310 EKMSKSLKNY 320 ITIKDFLKTF 330 SPDVFRLFCL 340 RTNYRSAIEY 350 SDSTLVEAKH 360 LLLGLASFVE 370 DARAYVKGQL 380 TCGPVEEDVL 390 WERLTSTKKA 400 VKAALANDFD 410 TPRAVNTILD 420 LVHHANRQLR 430 AVSKEASGPR 440 SPTVFGAIIS 450 YVEQFFETVG 460 ISLANRQCVS 470 GDSSTVTLRC 480 VVDELVRFRL 490 KVRQYALDTP 500 GAAGEARKRQ 510 LQERQPLLEA 520 CDTLRQDLVT 530 HGINVKDRGS 540 AASTWELLDP 550 RTRHQKPGDR G

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004817	cysteine-tRNA ligase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006423	cysteinyl-tRNA aminoacylation

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.