Search Results
Overview
| Uniprot ID | Q8BZP8 |
|---|---|
| Protein Name | Neuropeptide S receptor |
| Gene Name | Npsr1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | MKFLQGEKQAKVLIG |
Function
G protein-coupled receptor for neuropeptide S (NPS) (PubMed:31619542). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding
Protein Sequence
10
MPANLTEGSF
20
HANQTVPMLD
30
SSPVACTEIV
40
TFTEALVAEE
50
WGSFYSSFKT
60
EQLITLWVLF
70
VVTIVGNSVV
80
LFSTCRRKRK
90
SRMTFFVTQL
100
AITDSFTGLI
110
NILTDIIWRF
120
TGDFMAPDLV
130
CRVVRYLQVV
140
LLYASTYVLV
150
SLSIDRYHAI
160
VYPMKFLQGE
170
KQAKVLIGIA
180
WSLSFLFSIP
190
TLIIFGKRTL
200
SNGEVQCWAL
210
WPDDSYWTPY
220
MTIVAFLVYF
230
IPLAIISVIY
240
GLVIRTIWMK
250
SKTHETVISN
260
CSDGKLCCSY
270
NRGLISKAKI
280
KAIKYSIVII
290
LAFICCWSPY
300
FLFDILDNFN
310
VLPDTKERFY
320
ASVIIQNLPA
330
LNSAINPLIY
340
CIFSSSICSP
350
CKMQRSQDSR
360
MTYRERSERH
370
EMQILSKPEF
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008188 | neuropeptide receptor activity |
| Molecular Function | GO:0005000 | vasopressin receptor activity |
| Biological Process | GO:0042755 | eating behavior |
| Biological Process | GO:2000293 | negative regulation of defecation |
| Biological Process | GO:1903999 | negative regulation of eating behavior |
| Biological Process | GO:0007218 | neuropeptide signaling pathway |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0141163 | positive regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0060013 | righting reflex |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.