Search Results
Overview
| Uniprot ID | Q8CAQ8 |
|---|---|
| Protein Name | MICOS complex subunit Mic60 |
| Gene Name | Immt |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | YTVPLPKKPVQSGPL |
| 119 | SSVSEVMKDSKLPVA |
| 122 | SEVMKDSKLPVAQSQ |
| 130 | LPVAQSQKTKGDTPA |
| 268 | NSEIAGEKKSAQWRT |
| 281 | RTVEGALKERRKAVD |
| 285 | GALKERRKAVDEAAD |
| 352 | QAAQSEAKVVSQYHE |
| 370 | QARDDFRKELDSITP |
| 422 | NRELAQQKATEKQHI |
| 426 | AQQKATEKQHIELAL |
| 435 | HIELALEKHKLEEKR |
| 450 | TFDSAVAKALEHHRS |
| 498 | DHLRDVLKVQEQELK |
| 639 | ARFYAVQKLARRVAM |
| 713 | AKFVNQLKGESRRVA |
| 77 | HFRESVEKTIPYSDK |
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology
Protein Sequence
10
MLRACQLSGV
20
TVAAQSCLCG
30
KFVLRPLRPC
40
RRYSTSSSSG
50
LTAGKIAGAG
60
LLFVGGGIGG
70
TILYAKWDSH
80
FRESVEKTIP
90
YSDKLFGMVL
100
GSAPYTVPLP
110
KKPVQSGPLK
120
ISSVSEVMKD
130
SKLPVAQSQK
140
TKGDTPASAA
150
STGAAQIISA
160
AGDTLSVPAP
170
AVQHEDTIKT
180
ECPNTNEGKS
190
TSETTEEAFS
200
SSVRERPPEE
210
VAARLAQQEK
220
QEQVEMESLA
230
KSLEDALNRT
240
SSVTLQTITA
250
QNAAVQAVKA
260
HSNILKTAMD
270
NSEIAGEKKS
280
AQWRTVEGAL
290
KERRKAVDEA
300
ADALLKAKEE
310
LEKMKTIIED
320
AKKREIAGAT
330
PHITAAEGRL
340
HNMIVDLDNV
350
VKKVQAAQSE
360
AKVVSQYHEL
370
VVQARDDFRK
380
ELDSITPDIT
390
PGWKGMSISD
400
LAGKLSTDDL
410
NSLIAHAHRR
420
IDQLNRELAQ
430
QKATEKQHIE
440
LALEKHKLEE
450
KRTFDSAVAK
460
ALEHHRSEIQ
470
AEQDRKVEEV
480
RDAMENEMRT
490
QLRRQAAAHT
500
DHLRDVLKVQ
510
EQELKYEFEQ
520
GLSEKLSEQE
530
LEFRRRSQEQ
540
MDSFTLDINT
550
AYARLRGIEQ
560
AVQSHAVAEE
570
EARKAHQLWL
580
SVEALKYSMK
590
TSSAEMPTIP
600
LGSAVEAIRV
610
NCSDNEFTQA
620
LTAAIPPESL
630
TRGVYSEETL
640
RARFYAVQKL
650
ARRVAMIDET
660
RNSLYQYFLS
670
YLQSLLLFPP
680
KQLKPPAELY
690
PEDINTFKLL
700
SYASYCIEHG
710
DLELAAKFVN
720
QLKGESRRVA
730
QDWLKEARMT
740
LETKQIVEIL
750
TAYASAVGIG
TTQVQQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0061617 | MICOS complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Biological Process | GO:0042407 | cristae formation |
| Biological Process | GO:0051560 | mitochondrial calcium ion homeostasis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.