Search Results
Overview
| Uniprot ID | Q8CG76 |
|---|---|
| Protein Name | Aflatoxin B1 aldehyde reductase member 2 |
| Gene Name | Akr7a2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | PWEGKSLKPDSIRSQ |
| 136 | SQLETSLKRLQCPRV |
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity)
Protein Sequence
10
MLRAASRAVG
20
RAAVRSAQRS
30
GTSVGRPLAM
40
SRPPPPRAAS
50
GAPLRPATVL
60
GTMEMGRRMD
70
ASASAASVRA
80
FLERGHSELD
90
TAFMYCDGQS
100
ENILGGLGLG
110
LGSGDCTVKI
120
ATKANPWEGK
130
SLKPDSIRSQ
140
LETSLKRLQC
150
PRVDLFYLHA
160
PDHSTPVEET
170
LRACHQLHQE
180
GKFVELGLSN
190
YASWEVAEIC
200
TLCKSNGWIL
210
PTVYQGMYNA
220
TTRQVEAELL
230
PCLRHFGLRF
240
YAYNPLAGGL
250
LTGKYKYEDK
260
DGKQPVGRFF
270
GNNWAETYRN
280
RFWKEHHFEA
290
IALVEKALQT
300
TYGTNAPRMT
310
SAALRWMYHH
320
SQLQGTRGDA
330
VILGMSSLEQ
340
LEQNLAATEE
350
GPLEPAVVEA
360
FDQAWNMVAH
ECPNYFR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Molecular Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.