Search Results
Overview
| Uniprot ID | Q8CH40 |
|---|---|
| Protein Name | Nudix hydrolase 6 |
| Gene Name | Nudt6 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | VFEETGVKSEFRSLL |
| 255 | LENLARTKHTTPITS |
Function
Mediates the hydrolysis of some nucleoside diphosphate derivatives, such as NADH and FAD (in vitro). May modulate the subcellular levels of redox dinucleotides and control the mitochondrial concentrations of these compounds. May contribute to the regulation of cell proliferation
Protein Sequence
10
MWWVRRTRYW
20
FSTLLYAGGA
30
RLRPGRRTAS
40
GGLETPGSCG
50
AELQGELDRF
60
GGVSVHLSRH
70
HTLHGLDAAA
80
FRRLLQAAIQ
90
QWRSEGRIAA
100
WLHIPILQSH
110
FIAPAASLGF
120
CFHHAKPHSS
130
TLTLWLGEGP
140
SRLPGYATHQ
150
VGVAGAVFDV
160
STRKVLVVQD
170
RNKLKNMWKF
180
PGGLSEPGED
190
IADTAVREVF
200
EETGVKSEFR
210
SLLSIRQQHR
220
SPGAFGMSDM
230
YLVCRLQPRS
240
FTINFCQQEC
250
LKCEWIDLEN
260
LARTKHTTPI
270
TSRVARLLLY
280
GLREGFDKID
290
LSMEELPAVY
300
TGLFYKLYHR
310
ELPESYKAAT
GAD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0047631 | ADP-ribose diphosphatase activity |
| Molecular Function | GO:0047884 | FAD diphosphatase activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0035529 | NADH pyrophosphatase activity |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.