Search Results

Overview

Uniprot ID	Q8CHT0
Protein Name	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Gene Name	Aldh4a1
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
551	QVIKETHKPLGDWRY
98	AKFCYADKALLNRAI

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)

Protein Sequence

10 MLPLPSLRRS 20 LLSHAWRGAG 30 LRWKHTSSLK 40 VTNEPILAFS 50 QGSPERDALQ 60 KALKDLKGQM 70 EAIPCVVGDE 80 EVWTSDIQYQ 90 LSPFNHAHKV 100 AKFCYADKAL 110 LNRAIDAALA 120 ARKEWDLKPM 130 ADRAQVFLKA 140 ADMLSGPRRA 150 EVLAKTMVGQ 160 GKTVIQAEID 170 AAAELIDFFR 180 FNAKFAVELE 190 GEQPISVPPS 200 TNHTVYRGLE 210 GFVAAISPFN 220 FTAIGGNLAG 230 APALMGNVVL 240 WKPSDTAMLA 250 SYAVYRILRE 260 AGLPPNIIQF 270 VPADGPTFGD 280 TVTSSEHLCG 290 INFTGSVPTF 300 KHLWRQVAQN 310 LDRFRTFPRL 320 AGECGGKNFH 330 FVHSSADVDS 340 VVSGTLRSAF 350 EYGGQKCSAC 360 SRLYVPKSLW 370 PQIKGRLLEE 380 HSRIKVGDPA 390 EDFGTFFSAV 400 IDAKAFARIK 410 KWLEHARSSP 420 SLSILAGGQC 430 NESVGYYVEP 440 CIIESKDPQE 450 PIMKEEIFGP 460 VLTVYVYPDD 470 KYRETLQLVD 480 STTSYGLTGA 490 VFAQDKAIVQ 500 EATRMLRNAA 510 GNFYINDKST 520 GSVVGQQPFG 530 GARASGTNDK 540 PGGPHYILRW 550 TSPQVIKETH 560 KPLGDWRYSY MQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.