Search Results

Overview

Uniprot ID	Q8CI51
Protein Name	PDZ and LIM domain protein 5
Gene Name	Pdlim5
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
410	AEHIPAGKRTPMCAH
89	QRASAAAKSEPVSVQ

Function

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation

Protein Sequence

10 MSNYSVSLVG 20 PAPWGFRLQG 30 GKDFNMPLTI 40 SSLKDGGKAS 50 QAHVRIGDVV 60 LSIDGISAQG 70 MTHLEAQNKI 80 KACTGSLNMT 90 LQRASAAAKS 100 EPVSVQKGEP 110 KEVVKPVPIT 120 SPAVSKVTST 130 TNMAYNKAPR 140 PFGSVSSPKV 150 TSIPSPSSAF 160 TPAHAATSSH 170 ASPTPVAAAT 180 PLHLSASGLH 190 VSANLSADQC 200 SSPPNTGKPA 210 VNVPRQPTVT 220 SVCSESAQEL 230 AEGQRRGSQG 240 DIKQQNGPPR 250 KHIVERNTEF 260 YHIPTHSDAS 270 KKRLIEDTED 280 WRPRTGTTQS 290 RSFRILAQIT 300 GTEHLTESEN 310 DNTKKANSTQ 320 EPSQQPASSG 330 ASPLSASEGP 340 ESPGSSRPSV 350 AGLRSAAAFK 360 PVGSTSVKSP 370 SWQRPNQAAP 380 STGRISNNAR 390 SSGTGASVGP 400 PQPSDQDTLV 410 QRAEHIPAGK 420 RTPMCAHCNQ 430 VIRGPFLVAL 440 GKSWHPEEFN 450 CAHCKNTMAY 460 IGFVEEKGAL 470 YCELCYEKFF 480 APECGRCQRK 490 ILGEVINALK 500 QTWHVSCFVC 510 VACGKPIRNN 520 VFHLEDGEPY 530 CETDYYALFG 540 TICRGCEFPI 550 EAGDMFLEAL 560 GYTWHDTCFV 570 CSVCCESLEG 580 QTFFSKKDKP 590 LCKKHAHSVN F

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0001725	stress fiber
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0042805	actinin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051371	muscle alpha-actinin binding
Molecular Function	GO:0005080	protein kinase C binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development
Biological Process	GO:0007507	heart development
Biological Process	GO:0061061	muscle structure development
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis
Biological Process	GO:0150052	regulation of postsynapse assembly
Biological Process	GO:0051963	regulation of synapse assembly

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.