Search Results

Overview

Uniprot IDQ8CIZ8
Protein Namevon Willebrand factor
Gene NameVwf
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
773 SCRPPMVKLVCPADN

Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma

Protein Sequence

10 MNPFRYEICL 20 LVLALTWPGT 30 LCTEKPRDRP 40 STARCSLFGD 50 DFINTFDETM 60 YSFAGGCSYL 70 LAGDCQKRSF 80 SILGNFQDGK 90 RMSLSVYLGE 100 FFDIHLFANG 110 TVMQGDQSIS 120 MPYASQGLYL 130 ELEAGYYKLS 140 SETFGFAARI 150 DGNGNFQVLM 160 SDRHFNKTCG 170 LCGDFNIFAE 180 DDFRTQEGTL 190 TSDPYDFANS 200 WALSSEEQRC 210 KRASPPSRNC 220 ESSSGDMHQA 230 MWEQCQLLKT 240 ASVFARCHPL 250 VDPESFVALC 260 EKILCTCATG 270 PECACPVLLE 280 YARTCAQEGM 290 VLYGWTDHSA 300 CRPACPAGME 310 YKECVSPCPR 320 TCQSLSINEV 330 CQQQCVDGCS 340 CPEGELLDED 350 RCVQSSDCPC 360 VHAGKRYPPG 370 TSLSQDCNTC 380 ICRNSLWICS 390 NEECPGECLV 400 TGQSHFKSFD 410 NRYFTFSGIC 420 QYLLARDCED 430 HTFSIVIETM 440 QCADDPDAVC 450 TRSVSVRLSA 460 LHNSLVKLKH 470 GGAVGIDGQD 480 VQLPFLQGDL 490 RIQHTVMASV 500 RLSYAEDLQM 510 DWDGRGRLLV 520 KLSPVYSGKT 530 CGLCGNYNGN 540 KGDDFLTPAG 550 LVEPLVVDFG 560 NAWKLQGDCS 570 DLRRQHSDPC 580 SLNPRLTRFA 590 EEACALLTSS 600 KFEACHHAVS 610 PLPYLQNCRY 620 DVCSCSDSRD 630 CLCNAVANYA 640 AECARKGVHI 650 GWREPGFCAL 660 GCPQGQVYLQ 670 CGNSCNLTCR 680 SLSLPDEECS 690 EVCLEGCYCP 700 PGLYQDERGD 710 CVPKAQCPCY 720 YDGELFQPAD 730 IFSDHHTMCY 740 CEDGFMHCTT 750 SGTLGSLLPD 760 TVLSSPLSHR 770 SKRSLSCRPP 780 MVKLVCPADN 790 PRAQGLECAK 800 TCQNYDLERM 810 SLGCVSGCLC 820 PPGMVRHENK 830 CVALERCPCF 840 HQGAEYAPGD 850 TVKIGCNTCV 860 CRERKWNCTN 870 HVCDATRSAI 880 GMAHYLTFDG 890 LKYLFPGECQ 900 YVLVYDYCGS 910 NPGTFQILVG 920 NEGCSYPSVK 930 CRKRVTILVD 940 GGELELFDGE 950 VNVKRPLRDE 960 SHFEVVESGR 970 YVILLLGQAL 980 SVVWDHHLSI 990 SVVLKHTYQE 1000 QVCGLCGNFD 1010 GIQNNDSTTS 1020 SLQVEEDPVN 1030 FGNSWKVSSQ 1040 CADTRKLSLD 1050 VSPATCHNNI 1060 MKQTMVDSAC 1070 RILTSDVFQG 1080 CNRLVDPEPY 1090 LDICIYDTCS 1100 CESIGDCACF 1110 CDTIAAYAHV 1120 CAQHGQVVAW 1130 RTPTLCPQSC 1140 EEKNVRENGY 1150 ECEWRYNSCA 1160 PACPVTCQHP 1170 EPLACPVQCV 1180 EGCHAHCPPG 1190 RILDELLQTC 1200 VDPQDCPVCE 1210 VAGRRLAPGK 1220 KITLSPDDPA 1230 HCQNCHCDGV 1240 NLTCEACQEP 1250 GGLVAPPTDA 1260 PVSSTTPYVE 1270 DTPEPPLHNF 1280 YCSKLLDLVF 1290 LLDGSSMLSE 1300 AEFEVLKAFV 1310 VGMMERLHIS 1320 QKRIRVAVVE 1330 YHDGSRAYLE 1340 LKARKRPSEL 1350 RRITSQIKYT 1360 GSQVASTSEV 1370 LKYTLFQIFG 1380 KIDRPEASHI 1390 TLLLTASQEP 1400 PRMARNLVRY 1410 VQGLKKKKVI 1420 VIPVGIGPHA 1430 SLKQIRLIEK 1440 QAPENKAFLL 1450 SGVDELEQRR 1460 DEIVSYLCDL 1470 APEAPAPTQP 1480 PQVAHVTVSP 1490 GIAGISSPGP 1500 KRKSMVLDVV 1510 FVLEGSDEVG 1520 EANFNKSKEF 1530 VEEVIQRMDV 1540 SPDATRISVL 1550 QYSYTVTMEY 1560 AFNGAQSKEE 1570 VLRHVREIRY 1580 QGGNRTNTGQ 1590 ALQYLSEHSF 1600 SPSQGDRVEA 1610 PNLVYMVTGN 1620 PASDEIKRLP 1630 GDIQVVPIGV 1640 GPHANMQELE 1650 RISRPIAPIF 1660 IRDFETLPRE 1670 APDLVLQTCC 1680 SKEGLQLPTL 1690 PPLPDCSQPL 1700 DVVLLLDGSS 1710 SLPESSFDKM 1720 KSFAKAFISK 1730 ANIGPHLTQV 1740 SVIQYGSINT 1750 IDVPWNVVQE 1760 KAHLQSLVDL 1770 MQQEGGPSQI 1780 GDALAFAVRY 1790 VTSQIHGARP 1800 GASKAVVIII 1810 MDTSLDPVDT 1820 AADAARSNRV 1830 AVFPVGVGDR 1840 YDEAQLRILA 1850 GPGASSNVVK 1860 LQQVEDLSTM 1870 ATLGNSFFHK 1880 LCSGFSGVCV 1890 DEDGNEKRPG 1900 DVWTLPDQCH 1910 TVTCLANGQT 1920 LLQSHRVNCD 1930 HGPRPSCANS 1940 QSPVRVEETC 1950 GCRWTCPCVC 1960 TGSSTRHIVT 1970 FDGQNFKLTG 1980 SCSYVIFQNK 1990 EQDLEVLLHN 2000 GACSPGAKQA 2010 CMKSIEIKHA 2020 GVSAELHSNM 2030 EMAVDGRLVL 2040 APYVGENMEV 2050 SIYGAIMYEV 2060 RFTHLGHILT 2070 YTPQNNEFQL 2080 QLSPKTFASK 2090 MHGLCGICDE 2100 NGANDFTLRD 2110 GTVTTDWKRL 2120 VQEWTVQQPG 2130 YTCQAVPEEQ 2140 CPVSDSSHCQ 2150 VLLSASFAEC 2160 HKVIAPATFH 2170 TICQQDSCHQ 2180 ERVCEVIASY 2190 AHLCRTSGVC 2200 VDWRTTDFCA 2210 MSCPPSLVYN 2220 HCERGCPRHC 2230 DGNTSFCGDH 2240 PSEGCFCPQH 2250 QVFLEGSCVP 2260 EEACTQCVGE 2270 DGVRHQFLET 2280 WVPDHQPCQI 2290 CMCLSGRKIN 2300 CTAQPCPTAR 2310 APTCGPCEVA 2320 RLKQSTNLCC 2330 PEYECVCDLF 2340 NCNLPPVPPC 2350 EGGLQPTLTN 2360 PGECRPTFTC 2370 DCRKEECKRV 2380 SPPSCPPHRT 2390 PTLRKTQCCD 2400 EYECACSCVN 2410 STLSCPLGYL 2420 ASATTNDCGC 2430 TTTTCLPDKV 2440 CVHRGTVYPV 2450 GQFWEEGCDT 2460 CTCTDMEDTV 2470 VGLRVVQCSQ 2480 RPCEDSCQPG 2490 FSYVLHEGEC 2500 CGRCLPSACK 2510 VVAGSLRGDS 2520 HSSWKSVGSR 2530 WAVPENPCLV 2540 NECVRVEDAV 2550 FVQQRNISCP 2560 QLAVPTCPTG 2570 FQLNCETSEC 2580 CPSCHCEPVE 2590 ACLLNGTIIG 2600 PGKSVMVDLC 2610 TTCRCIVQTD 2620 AISRFKLECR 2630 KTTCEACPMG 2640 YREEKSQGEC 2650 CGRCLPTACT 2660 IQLRGGRIMT 2670 LKQDETFQDG 2680 CDSHLCRVNE 2690 RGEYIWEKRV 2700 TGCPPFDEHK 2710 CLAEGGKIVK 2720 IPGTCCDTCE 2730 EPDCKDITAK 2740 VQYIKVGDCK 2750 SQEEVDIHYC 2760 QGKCASKAVY 2770 SIDIEDVQEQ 2780 CSCCLPSRTE 2790 PMRVPLHCTN 2800 GSVVYHEVIN 2810 AMQCRCSPRN CSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0033093 Weibel-Palade body
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019865 immunoglobulin binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0051087 protein-folding chaperone binding
Biological Process GO:0002543 activation of blood coagulation via clotting cascade
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007155 cell adhesion
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0007599 hemostasis
Biological Process GO:0006954 inflammatory response
Biological Process GO:0001889 liver development
Biological Process GO:0001890 placenta development
Biological Process GO:0030168 platelet activation
Biological Process GO:1902533 positive regulation of intracellular signal transduction
Biological Process GO:1901731 positive regulation of platelet aggregation

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.