Search Results
Overview
| Uniprot ID | Q8HXL4 |
|---|---|
| Protein Name | Tubulin-folding cofactor B |
| Gene Name | TBCB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | MSKVEKYKISQEAYD |
| 38 | SLTVAEFKDKLQLVV |
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth
Protein Sequence
10
MEVTGLSAPT
20
VTVFISSSLN
30
SFRSQKRYSR
40
SLTVAEFKDK
50
LQLVVGSPAS
60
CMELELYGPD
70
DKFYVKLDQE
80
DALLGSYPVD
90
DGCRIHVIDH
100
SGARLGEYED
110
MSKVEKYKIS
120
QEAYDQRQNS
130
VRSFLKRNKL
140
GRYNEEERAQ
150
REAESSQRLI
160
EEEAQASAIP
170
VGSRCEVRAP
180
GQPPRRGTVM
190
YVGLTDFKPG
200
YWIGVRYDEP
210
LGKNDGSVNG
220
KRYFECQAKY
230
GAFVKPSVVT
240
VGDFPEEDYG
LDEM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007023 | post-chaperonin tubulin folding pathway |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.