Search Results

Overview

Uniprot IDQ8HZV3
Protein NameTransferrin receptor protein 1
Gene NameTFRC
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
140 DLKILLSKGLDTTDF
269 LVIVRAGKITFAEKV
372 WRTDFPCKLVSSPSK
379 KLVSSPSKNVKLTVN
382 SSPSKNVKLTVNNVL
539 RDSNWINKVEKLSFD

Function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity)

Protein Sequence

10 MMDQARSAFS 20 SLFGGEPLSY 30 TRFSLARQVD 40 GDNSHVEMKL 50 AADEEENVDS 60 NTRSNHIGVA 70 KPKRLNGYVC 80 YGIIAVITFF 90 LIGFMIGYLA 100 YCKRVESKTD 110 CKTLVPTEPS 120 ETEETETFEA 130 ENFPQTPRLF 140 WADLKILLSK 150 GLDTTDFTRT 160 IKMLNEDYAP 170 REAGSQKDES 180 LGFFIENQFR 190 EFKLSKVWHD 200 EHFVKIQVKG 210 SNAENSVTLV 220 NTDSNSLVYP 230 VESPEGYVAY 240 SKATTVTGKL 250 IFANFGTKKD 260 FEDLKMPVNG 270 SLVIVRAGKI 280 TFAEKVANAQ 290 SLDAIGVLIY 300 MDRANFPIIN 310 ADVPVFGHAH 320 LGTGDPYTPG 330 FPSFNHTQFP 340 PSQSSGLPNI 350 PVQTISRAGA 360 EKLFGNMEQD 370 CPLTWRTDFP 380 CKLVSSPSKN 390 VKLTVNNVLK 400 EIKILNIFGV 410 IKGFEEPDRY 420 VIVGAQRDAW 430 GPGAAKSSVG 440 TSLLLNLAQI 450 LSDMVIKGQF 460 KPSRSIVFAS 470 WSAGDFGAIG 480 ATEWLEGYLS 490 SLHLKAFTYI 500 NLDKAVLGTS 510 NFKVSASPLL 520 YSLIEKMMQD 530 VKNPVTGQSL 540 YRDSNWINKV 550 EKLSFDDAAF 560 PFLAYSGIPA 570 VSFCFCEDTD 580 YPYLGTTMDT 590 YDVLSKRVPQ 600 LNRMARAAAE 610 VAGHLVIKLT 620 IDFELNLNYE 630 MYNDKILSFV 640 REMNQFRVDI 650 REMGLSLQWL 660 YSARGDFFRA 670 TSRLTSDYRN 680 VETRDKFVMR 690 EINDRIMKVE 700 YHFLSPYVSP 710 RESPFRHIFW 720 GSGSHTLSAL 730 VEHLKLRQKN 740 SSAFNQTLLK 750 NQLALATWTI 760 QGAANALSGD IWDIDNEF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0055037 recycling endosome
Molecular Function GO:0004998 transferrin receptor activity
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006826 iron ion transport
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0045830 positive regulation of isotype switching
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0031623 receptor internalization
Biological Process GO:0033572 transferrin transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.