Search Results

Overview

Uniprot IDQ8IU80
Protein NameTransmembrane protease serine 6
Gene NameTMPRSS6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
8 MLLLFHSKRMPVAEA

Function

Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18408718, PubMed:18976966, PubMed:25156943)

Protein Sequence

10 MLLLFHSKRM 20 PVAEAPQVAG 30 GQGDGGDGEE 40 AEPEGMFKAC 50 EDSKRKARGY 60 LRLVPLFVLL 70 ALLVLASAGV 80 LLWYFLGYKA 90 EVMVSQVYSG 100 SLRVLNRHFS 110 QDLTRRESSA 120 FRSETAKAQK 130 MLKELITSTR 140 LGTYYNSSSV 150 YSFGEGPLTC 160 FFWFILQIPE 170 HRRLMLSPEV 180 VQALLVEELL 190 STVNSSAAVP 200 YRAEYEVDPE 210 GLVILEASVK 220 DIAALNSTLG 230 CYRYSYVGQG 240 QVLRLKGPDH 250 LASSCLWHLQ 260 GPKDLMLKLR 270 LEWTLAECRD 280 RLAMYDVAGP 290 LEKRLITSVY 300 GCSRQEPVVE 310 VLASGAIMAV 320 VWKKGLHSYY 330 DPFVLSVQPV 340 VFQACEVNLT 350 LDNRLDSQGV 360 LSTPYFPSYY 370 SPQTHCSWHL 380 TVPSLDYGLA 390 LWFDAYALRR 400 QKYDLPCTQG 410 QWTIQNRRLC 420 GLRILQPYAE 430 RIPVVATAGI 440 TINFTSQISL 450 TGPGVRVHYG 460 LYNQSDPCPG 470 EFLCSVNGLC 480 VPACDGVKDC 490 PNGLDERNCV 500 CRATFQCKED 510 STCISLPKVC 520 DGQPDCLNGS 530 DEEQCQEGVP 540 CGTFTFQCED 550 RSCVKKPNPQ 560 CDGRPDCRDG 570 SDEEHCDCGL 580 QGPSSRIVGG 590 AVSSEGEWPW 600 QASLQVRGRH 610 ICGGALIADR 620 WVITAAHCFQ 630 EDSMASTVLW 640 TVFLGKVWQN 650 SRWPGEVSFK 660 VSRLLLHPYH 670 EEDSHDYDVA 680 LLQLDHPVVR 690 SAAVRPVCLP 700 ARSHFFEPGL 710 HCWITGWGAL 720 REGGPISNAL 730 QKVDVQLIPQ 740 DLCSEVYRYQ 750 VTPRMLCAGY 760 RKGKKDACQG 770 DSGGPLVCKA 780 LSGRWFLAGL 790 VSWGLGCGRP 800 NYFGVYTRIT 810 GVISWIQQVV T

Gene Ontology

Classification GO ID Description
Biological Process GO:0022617 extracellular matrix disassembly
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004222 metalloendopeptidase activity
Molecular Function GO:0004252 serine-type endopeptidase activity
Molecular Function GO:0008236 serine-type peptidase activity
Biological Process GO:0030574 collagen catabolic process
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0033619 membrane protein proteolysis
Biological Process GO:0060586 multicellular organismal-level iron ion homeostasis
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016485 protein processing
Biological Process GO:0097264 self proteolysis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.