Search Results

Overview

Uniprot ID	Q8IU81
Protein Name	Interferon regulatory factor 2-binding protein 1
Gene Name	IRF2BP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
306	DALREPGKALASSGF
382	APTPRRRKASPEPEG
438	EALGHSPKDPGGGGG

Function

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation

Protein Sequence

10 MASVQASRRQ 20 WCYLCDLPKM 30 PWAMVWDFSE 40 AVCRGCVNFE 50 GADRIELLID 60 AARQLKRSHV 70 LPEGRSPGPP 80 ALKHPATKDL 90 AAAAAQGPQL 100 PPPQAQPQPS 110 GTGGGVSGQD 120 RYDRATSSGR 130 LPLPSPALEY 140 TLGSRLANGL 150 GREEAVAEGA 160 RRALLGSMPG 170 LMPPGLLAAA 180 VSGLGSRGLT 190 LAPGLSPARP 200 LFGSDFEKEK 210 QQRNADCLAE 220 LNEAMRGRAE 230 EWHGRPKAVR 240 EQLLALSACA 250 PFNVRFKKDH 260 GLVGRVFAFD 270 ATARPPGYEF 280 ELKLFTEYPC 290 GSGNVYAGVL 300 AVARQMFHDA 310 LREPGKALAS 320 SGFKYLEYER 330 RHGSGEWRQL 340 GELLTDGVRS 350 FREPAPAEAL 360 PQQYPEPAPA 370 ALCGPPPRAP 380 SRNLAPTPRR 390 RKASPEPEGE 400 AAGKMTTEEQ 410 QQRHWVAPGG 420 PYSAETPGVP 430 SPIAALKNVA 440 EALGHSPKDP 450 GGGGGPVRAG 460 GASPAASSTA 470 QPPTQHRLVA 480 RNGEAEVSPT 490 AGAEAVSGGG 500 SGTGATPGAP 510 LCCTLCRERL 520 EDTHFVQCPS 530 VPGHKFCFPC 540 SREFIKAQGP 550 AGEVYCPSGD 560 KCPLVGSSVP 570 WAFMQGEIAT 580 ILAGDIKVKK ERDP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.