Overview
| Uniprot ID | Q8IU85 |
|---|
| Protein Name | Calcium/calmodulin-dependent protein kinase type 1D |
|---|
| Gene Name | CAMK1D |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 52 |
TGKLFAVKCIPKKAL |
| 62 |
PKKALKGKESSIENE |
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta
Protein Sequence
10
MARENGESSS
20
SWKKQAEDIK
30
KIFEFKETLG
40
TGAFSEVVLA
50
EEKATGKLFA
60
VKCIPKKALK
70
GKESSIENEI
80
AVLRKIKHEN
90
IVALEDIYES
100
PNHLYLVMQL
110
VSGGELFDRI
120
VEKGFYTEKD
130
ASTLIRQVLD
140
AVYYLHRMGI
150
VHRDLKPENL
160
LYYSQDEESK
170
IMISDFGLSK
180
MEGKGDVMST
190
ACGTPGYVAP
200
EVLAQKPYSK
210
AVDCWSIGVI
220
AYILLCGYPP
230
FYDENDSKLF
240
EQILKAEYEF
250
DSPYWDDISD
260
SAKDFIRNLM
270
EKDPNKRYTC
280
EQAARHPWIA
290
GDTALNKNIH
300
ESVSAQIRKN
310
FAKSKWRQAF
320
NATAVVRHMR
330
KLHLGSSLDS
340
SNASVSSSLS
350
LASQKDCLAP
360
STLCSFISSS
370
SGVSGVGAER
380
RPRPTTVTAV
HSGSK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004683 |
calcium/calmodulin-dependent protein kinase activity |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0090023 |
positive regulation of neutrophil chemotaxis |
| Biological Process |
GO:0050766 |
positive regulation of phagocytosis |
| Biological Process |
GO:0060267 |
positive regulation of respiratory burst |
| Biological Process |
GO:0050773 |
regulation of dendrite development |
| Biological Process |
GO:0071622 |
regulation of granulocyte chemotaxis |
| Biological Process |
GO:0010975 |
regulation of neuron projection development |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.