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Overview

Uniprot ID	Q8IUC4
Protein Name	Rhophilin-2
Gene Name	RHPN2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
35	LAQTGRSKLQNQRAA

Function

Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity

Protein Sequence

10 MTDALLPAAP 20 QPLEKENDGY 30 FRKGCNPLAQ 40 TGRSKLQNQR 50 AALNQQILKA 60 VRMRTGAENL 70 LKVATNSKVR 80 EQVRLELSFV 90 NSDLQMLKEE 100 LEGLNISVGV 110 YQNTEEAFTI 120 PLIPLGLKET 130 KDVDFAVVLK 140 DFILEHYSED 150 GYLYEDEIAD 160 LMDLRQACRT 170 PSRDEAGVEL 180 LMTYFIQLGF 190 VESRFFPPTR 200 QMGLLFTWYD 210 SLTGVPVSQQ 220 NLLLEKASVL 230 FNTGALYTQI 240 GTRCDRQTQA 250 GLESAIDAFQ 260 RAAGVLNYLK 270 DTFTHTPSYD 280 MSPAMLSVLV 290 KMMLAQAQES 300 VFEKISLPGI 310 RNEFFMLVKV 320 AQEAAKVGEV 330 YQQLHAAMSQ 340 APVKENIPYS 350 WASLACVKAH 360 HYAALAHYFT 370 AILLIDHQVK 380 PGTDLDHQEK 390 CLSQLYDHMP 400 EGLTPLATLK 410 NDQQRRQLGK 420 SHLRRAMAHH 430 EESVREASLC 440 KKLRSIEVLQ 450 KVLCAAQERS 460 RLTYAQHQEE 470 DDLLNLIDAP 480 SVVAKTEQEV 490 DIILPQFSKL 500 TVTDFFQKLG 510 PLSVFSANKR 520 WTPPRSIRFT 530 AEEGDLGFTL 540 RGNAPVQVHF 550 LDPYCSASVA 560 GAREGDYIVS 570 IQLVDCKWLT 580 LSEVMKLLKS 590 FGEDEIEMKV 600 VSLLDSTSSM 610 HNKSATYSVG 620 MQKTYSMICL 630 AIDDDDKTDK 640 TKKISKKLSF 650 LSWGTNKNRQ 660 KSASTLCLPS 670 VGAARPQVKK 680 KLPSPFSLLN SDSSWY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Biological Process	GO:0051497	negative regulation of stress fiber assembly
Biological Process	GO:0007165	signal transduction

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.