Search Results

Overview

Uniprot IDQ8IUD2
Protein NameELKS/Rab6-interacting/CAST family member 1
Gene NameERC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 GSARSVGKVEPSSQS
159 MDLQTQLKEVLREND
212 ASKITIWKEQYRVVQ
578 RKVNVLQKKIENLQE
883 ELLMAMEKVKQELES

Function

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport

Protein Sequence

10 MYGSARSVGK 20 VEPSSQSPGR 30 SPRLPRSPRL 40 GHRRTNSTGG 50 SSGSSVGGGS 60 GKTLSMENIQ 70 SLNAAYATSG 80 PMYLSDHENV 90 GSETPKSTMT 100 LGRSGGRLPY 110 GVRMTAMGSS 120 PNIASSGVAS 130 DTIAFGEHHL 140 PPVSMASTVP 150 HSLRQARDNT 160 IMDLQTQLKE 170 VLRENDLLRK 180 DVEVKESKLS 190 SSMNSIKTFW 200 SPELKKERAL 210 RKDEASKITI 220 WKEQYRVVQE 230 ENQHMQMTIQ 240 ALQDELRIQR 250 DLNQLFQQDS 260 SSRTGEPCVA 270 ELTEENFQRL 280 HAEHERQAKE 290 LFLLRKTLEE 300 MELRIETQKQ 310 TLNARDESIK 320 KLLEMLQSKG 330 LSAKATEEDH 340 ERTRRLAEAE 350 MHVHHLESLL 360 EQKEKENSML 370 REEMHRRFEN 380 APDSAKTKAL 390 QTVIEMKDSK 400 ISSMERGLRD 410 LEEEIQMLKS 420 NGALSTEERE 430 EEMKQMEVYR 440 SHSKFMKNKV 450 EQLKEELSSK 460 EAQWEELKKK 470 AAGLQAEIGQ 480 VKQELSRKDT 490 ELLALQTKLE 500 TLTNQFSDSK 510 QHIEVLKESL 520 TAKEQRAAIL 530 QTEVDALRLR 540 LEEKETMLNK 550 KTKQIQDMAE 560 EKGTQAGEIH 570 DLKDMLDVKE 580 RKVNVLQKKI 590 ENLQEQLRDK 600 EKQMSSLKER 610 VKSLQADTTN 620 TDTALTTLEE 630 ALAEKERTIE 640 RLKEQRDRDE 650 REKQEEIDNY 660 KKDLKDLKEK 670 VSLLQGDLSE 680 KEASLLDLKE 690 HASSLASSGL 700 KKDSRLKTLE 710 IALEQKKEEC 720 LKMESQLKKA 730 HEAALEARAS 740 PEMSDRIQHL 750 EREITRYKDE 760 SSKAQAEVDR 770 LLEILKEVEN 780 EKNDKDKKIA 790 ELERQVKDQN 800 KKVANLKHKE 810 QVEKKKSAQM 820 LEEARRREDN 830 LNDSSQQLQD 840 SLRKKDDRIE 850 ELEEALRESV 860 QITAEREMVL 870 AQEESARTNA 880 EKQVEELLMA 890 MEKVKQELES 900 MKAKLSSTQQ 910 SLAEKETHLT 920 NLRAERRKHL 930 EEVLEMKQEA 940 LLAAISEKDA 950 NIALLELSSS 960 KKKTQEEVAA 970 LKREKDRLVQ 980 QLKQQTQNRM 990 KLMADNYEDD 1000 HFKSSHSNQT 1010 NHKPSPDQII 1020 QPLLELDQNR 1030 SKLKLYIGHL 1040 TTLCHDRDPL 1050 ILRGLTPPAS 1060 YNLDDDQAAW 1070 ENELQKMTRG 1080 QLQDELEKGE 1090 RDNAELQEFA 1100 NAILQQIADH 1110 CPDILEQVVN ALEESS

Gene Ontology

Classification GO ID Description
Molecular Function GO:0045296 cadherin binding
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0008385 IkappaB kinase complex
Cellular Component GO:0002102 podosome
Cellular Component GO:0098831 presynaptic active zone cytoplasmic component
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0098882 structural constituent of presynaptic active zone
Biological Process GO:0048790 maintenance of presynaptic active zone structure
Biological Process GO:0043123 positive regulation of canonical NF-kappaB signal transduction
Biological Process GO:0015031 protein transport
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.