Search Results
Overview
| Uniprot ID | Q8IUF8 |
|---|---|
| Protein Name | Ribosomal oxygenase 2 |
| Gene Name | RIOX2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | EEGPAPCKQMKLEAA |
Function
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles
Protein Sequence
10
MPKKAKPTGS
20
GKEEGPAPCK
30
QMKLEAAGGP
40
SALNFDSPSS
50
LFESLISPIK
60
TETFFKEFWE
70
QKPLLIQRDD
80
PALATYYGSL
90
FKLTDLKSLC
100
SRGMYYGRDV
110
NVCRCVNGKK
120
KVLNKDGKAH
130
FLQLRKDFDQ
140
KRATIQFHQP
150
QRFKDELWRI
160
QEKLECYFGS
170
LVGSNVYITP
180
AGSQGLPPHY
190
DDVEVFILQL
200
EGEKHWRLYH
210
PTVPLAREYS
220
VEAEERIGRP
230
VHEFMLKPGD
240
LLYFPRGTIH
250
QADTPAGLAH
260
STHVTISTYQ
270
NNSWGDFLLD
280
TISGLVFDTA
290
KEDVELRTGI
300
PRQLLLQVES
310
TTVATRRLSG
320
FLRTLADRLE
330
GTKELLSSDM
340
KKDFIMHRLP
350
PYSAGDGAEL
360
STPGGKLPRL
370
DSVVRLQFKD
380
HIVLTVLPDQ
390
DQSDEAQEKM
400
VYIYHSLKNS
410
RETHMMGNEE
420
ETEFHGLRFP
430
LSHLDALKQI
440
WNSPAISVKD
450
LKLTTDEEKE
460
SLVLSLWTEC
LIQVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0032452 | histone demethylase activity |
| Molecular Function | GO:0051864 | histone H3K36 demethylase activity |
| Molecular Function | GO:0032453 | histone H3K4 demethylase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0036139 | peptidyl-histidine dioxygenase activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0018126 | protein hydroxylation |
| Biological Process | GO:0042254 | ribosome biogenesis |
Reference
PMID: N/A