Search Results

Overview

Uniprot IDQ8IUX7
Protein NameAdipocyte enhancer-binding protein 1
Gene NameAEBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
592 TRTYSLGKSSRGLKI

Function

As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix

Protein Sequence

10 MAAVRGAPLL 20 SCLLALLALC 30 PGGRPQTVLT 40 DDEIEEFLEG 50 FLSELEPEPR 60 EDDVEAPPPP 70 EPTPRVRKAQ 80 AGGKPGKRPG 90 TAAEVPPEKT 100 KDKGKKGKKD 110 KGPKVPKESL 120 EGSPRPPKKG 130 KEKPPKATKK 140 PKEKPPKATK 150 KPKEKPPKAT 160 KKPKEKPPKA 170 TKKPPSGKRP 180 PILAPSETLE 190 WPLPPPPSPG 200 PEELPQEGGA 210 PLSNNWQNPG 220 EETHVEAREH 230 QPEPEEETEQ 240 PTLDYNDQIE 250 REDYEDFEYI 260 RRQKQPRPPP 270 SRRRRPERVW 280 PEPPEEKAPA 290 PAPEERIEPP 300 VKPLLPPLPP 310 DYGDGYVIPN 320 YDDMDYYFGP 330 PPPQKPDAER 340 QTDEEKEELK 350 KPKKEDSSPK 360 EETDKWAVEK 370 GKDHKEPRKG 380 EELEEEWTPT 390 EKVKCPPIGM 400 ESHRIEDNQI 410 RASSMLRHGL 420 GAQRGRLNMQ 430 TGATEDDYYD 440 GAWCAEDDAR 450 TQWIEVDTRR 460 TTRFTGVITQ 470 GRDSSIHDDF 480 VTTFFVGFSN 490 DSQTWVMYTN 500 GYEEMTFHGN 510 VDKDTPVLSE 520 LPEPVVARFI 530 RIYPLTWNGS 540 LCMRLEVLGC 550 SVAPVYSYYA 560 QNEVVATDDL 570 DFRHHSYKDM 580 RQLMKVVNEE 590 CPTITRTYSL 600 GKSSRGLKIY 610 AMEISDNPGE 620 HELGEPEFRY 630 TAGIHGNEVL 640 GRELLLLLMQ 650 YLCREYRDGN 660 PRVRSLVQDT 670 RIHLVPSLNP 680 DGYEVAAQMG 690 SEFGNWALGL 700 WTEEGFDIFE 710 DFPDLNSVLW 720 GAEERKWVPY 730 RVPNNNLPIP 740 ERYLSPDATV 750 STEVRAIIAW 760 MEKNPFVLGA 770 NLNGGERLVS 780 YPYDMARTPT 790 QEQLLAAAMA 800 AARGEDEDEV 810 SEAQETPDHA 820 IFRWLAISFA 830 SAHLTLTEPY 840 RGGCQAQDYT 850 GGMGIVNGAK 860 WNPRTGTIND 870 FSYLHTNCLE 880 LSFYLGCDKF 890 PHESELPREW 900 ENNKEALLTF 910 MEQVHRGIKG 920 VVTDEQGIPI 930 ANATISVSGI 940 NHGVKTASGG 950 DYWRILNPGE 960 YRVTAHAEGY 970 TPSAKTCNVD 980 YDIGATQCNF 990 ILARSNWKRI 1000 REIMAMNGNR 1010 PIPHIDPSRP 1020 MTPQQRRLQQ 1030 RRLQHRLRLR 1040 AQMRLRRLNA 1050 TTTLGPHTVP 1060 PTLPPAPATT 1070 LSTTIEPWGL 1080 IPPTTAGWEE 1090 SETETYTEVV 1100 TEFGTEVEPE 1110 FGTKVEPEFE 1120 TQLEPEFETQ 1130 LEPEFEEEEE 1140 EEKEEEIATG 1150 QAFPFTTVET YTVNFGDF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0004180 carboxypeptidase activity
Molecular Function GO:0005518 collagen binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006508 proteolysis
Biological Process GO:1904026 regulation of collagen fibril organization
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.