Search Results
Overview
| Uniprot ID | Q8IUZ5 |
|---|---|
| Protein Name | 5-phosphohydroxy-L-lysine phospho-lyase |
| Gene Name | PHYKPL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 203 | VVSSAQEKGRKIAAF |
| 412 | GRNILKFKPPMCFSL |
Function
Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde
Protein Sequence
10
MAADQRPKAD
20
TLALRQRLIS
30
SSCRLFFPED
40
PVKIVRAQGQ
50
YMYDEQGAEY
60
IDCISNVAHV
70
GHCHPLVVQA
80
AHEQNQVLNT
90
NSRYLHDNIV
100
DYAQRLSETL
110
PEQLCVFYFL
120
NSGSEANDLA
130
LRLARHYTGH
140
QDVVVLDHAY
150
HGHLSSLIDI
160
SPYKFRNLDG
170
QKEWVHVAPL
180
PDTYRGPYRE
190
DHPNPAMAYA
200
NEVKRVVSSA
210
QEKGRKIAAF
220
FAESLPSVGG
230
QIIPPAGYFS
240
QVAEHIRKAG
250
GVFVADEIQV
260
GFGRVGKHFW
270
AFQLQGKDFV
280
PDIVTMGKSI
290
GNGHPVACVA
300
ATQPVARAFE
310
ATGVEYFNTF
320
GGSPVSCAVG
330
LAVLNVLEKE
340
QLQDHATSVG
350
SFLMQLLGQQ
360
KIKHPIVGDV
370
RGVGLFIGVD
380
LIKDEATRTP
390
ATEEAAYLVS
400
RLKENYVLLS
410
TDGPGRNILK
420
FKPPMCFSLD
430
NARQVVAKLD
440
AILTDMEEKV
450
RSCETLRLQP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0016829 | lyase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0042802 | identical protein binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.