Search Results

Overview

Uniprot IDQ8IVF4
Protein NameDynein axonemal heavy chain 10
Gene NameDNAH10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
583 RSLFFRIKHTILRFQ
607 RGQEVKQKYLEVGRT

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (PubMed:34237282). Probable inner arm dynein heavy chain

Protein Sequence

10 MVPEEVEVEI 20 DEIPVLSEEG 30 EEEEETYSQK 40 VESVDKVRAK 50 RVSLRTESLG 60 QPLNREDEEM 70 DKEISEKLPS 80 KRTAKHIMEK 90 MHLHMLCTPL 100 PEEFLDQNVV 110 FFLRNTKEAI 120 SEATDMKEAM 130 EIMPETLEYG 140 IINANVLHFL 150 KNIICQVFLP 160 ALSFNQHRTS 170 TTVGVTSGEV 180 SNSSEHESDL 190 PPMPGEAVEY 200 HSIQLIRDEF 210 LMNVQKFASN 220 IQRTMQQLEG 230 EIKLEMPIIS 240 VEGEVSDLAA 250 DPETVDILEQ 260 CVINWLNQIS 270 TAVEAQLKKT 280 PQGKGPLAEI 290 EFWRERNATL 300 SALHEQTKLP 310 IVRKVLDVIK 320 ESDSMLVANL 330 QPVFTELFKF 340 HTEASDNVRF 350 LSTVERYFKN 360 ITHGSGFHVV 370 LDTIPAMMSA 380 LRMVWIISRH 390 YNKDERMIPL 400 MERIAWEIAE 410 RVCRVVNLRT 420 LFKENRASAQ 430 SKTLEARNTL 440 RLWKKAYFDT 450 RAKIEASGRE 460 DRWEFDRKRL 470 FERTDYMATI 480 CQDLSDVLQI 490 LEEFYNIFGP 500 ELKAVTGDPK 510 RIDDVLCRVD 520 GLVTPMENLT 530 FDPFSIKSSQ 540 FWKYVMDEFK 550 IEVLIDIINK 560 IFVQNLENPP 570 LYKNHPPVAG 580 AIYWERSLFF 590 RIKHTILRFQ 600 EVQEILDSDR 610 GQEVKQKYLE 620 VGRTMKEYED 630 RKYEQWMEVT 640 EQVLPALMKK 650 SLLTKSSIAT 660 EEPSTLERGA 670 VFAINFSPAL 680 REIINETKYL 690 EQLGFTVPEL 700 ARNVALQEDK 710 FLRYTAGIQR 720 MLDHYHMLIG 730 TLNDAESVLL 740 KDHSQELLRV 750 FRSGYKRLNW 760 NSLGIGDYIT 770 GCKQAIGKFE 780 SLVHQIHKNA 790 DDISSRLTLI 800 EAINLFKYPA 810 AKSEEELPGV 820 KEFFEHIERE 830 RASDVDHMVR 840 WYLAIGPLLT 850 KVEGLVVHTN 860 TGKAPKLASY 870 YKYWEKKIYE 880 VLTKLILKNL 890 QSFNSLILGN 900 VPLFHTETIL 910 TAPEIILHPN 920 TNEIDKMCFH 930 CVRNCVEITK 940 HFVRWMNGSC 950 IECPPQKGEE 960 EEVVIINFYN 970 DISLNPQIIE 980 QAVMIPQNVH 990 RILINLMKYL 1000 QKWKRYRPLW 1010 KLDKAIVMEK 1020 FAAKKPPCVA 1030 YDEKLQFYSK 1040 IAYEVMRHPL 1050 IKDEHCIRLQ 1060 LRHLANTVQE 1070 NAKSWVISLG 1080 KLLNESAKEE 1090 LYNLHEEMEH 1100 LAKNLRKIPN 1110 TLEDLKFVLA 1120 TIAEIRSKSL 1130 VMELRYRDVQ 1140 ERYRTMAMYN 1150 LFPPDAEKEL 1160 VDKIESIWSN 1170 LFNDSVNVEH 1180 ALGDIKRTFT 1190 ELTRGEIMNY 1200 RVQIEEFAKR 1210 FYSEGPGSVG 1220 DDLDKGVELL 1230 GVYERELARH 1240 EKSRQELANA 1250 EKLFDLPITM 1260 YPELLKVQKE 1270 MSGLRMIYEL 1280 YEGLKVAKEE 1290 WSQTLWINLN 1300 VQILQEGIEG 1310 FLRALRKLPR 1320 PVRGLSVTYY 1330 LEAKMKAFKD 1340 SIPLLLDLKN 1350 EALRDRHWKE 1360 LMEKTSVFFE 1370 MTETFTLENM 1380 FAMELHKHTD 1390 VLNEIVTAAI 1400 KEVAIEKAVK 1410 EILDTWENMK 1420 FTVVKYCKGT 1430 QERGYILGSV 1440 DEIIQSLDDN 1450 TFNLQSISGS 1460 RFVGPFLQTV 1470 HKWEKTLSLI 1480 GEVIEIWMLV 1490 QRKWMYLESI 1500 FIGGDIRSQL 1510 PEEAKKFDNI 1520 DKVFKRIMGE 1530 TLKDPVIKRC 1540 CEAPNRLSDL 1550 QNVSEGLEKC 1560 QKSLNDYLDS 1570 KRNAFPRFFF 1580 ISDDELLSIL 1590 GSSDPLCVQE 1600 HMIKMYDNIA 1610 SLRFNDGDSG 1620 EKLVSAMISA 1630 EGEVMEFRKI 1640 LRAEGRVEDW 1650 MTAVLNEMRR 1660 TNRLITKEAI 1670 FRYCEDRSRV 1680 DWMLLYQGMV 1690 VLAASQVWWT 1700 WEVEDVFHKA 1710 QKGEKQAMKN 1720 YGRKMHRQID 1730 ELVTRITMPL 1740 SKNDRKKYNT 1750 VLIIDVHARD 1760 IVDSFIRGSI 1770 LEAREFDWES 1780 QLRFYWDREP 1790 DELNIRQCTG 1800 TFGYGYEYMG 1810 LNGRLVITPL 1820 TDRIYLTLTQ 1830 ALSMYLGGAP 1840 AGPAGTGKTE 1850 TTKDLAKALG 1860 LLCVVTNCGE 1870 GMDYRAVGKI 1880 FSGLAQCGAW 1890 GCFDEFNRID 1900 ASVLSVISSQ 1910 IQTIRNALIH 1920 QLTTFQFEGQ 1930 EISLDSRMGI 1940 FITMNPGYAG 1950 RTELPESVKA 1960 LFRPVVVIVP 1970 DLQQICEIML 1980 FSEGFLEAKT 1990 LAKKMTVLYK 2000 LAREQLSKQY 2010 HYDFGLRALK 2020 SVLVMAGELK 2030 RGSSDLREDV 2040 VLMRALRDMN 2050 LPKFVFEDVP 2060 LFLGLISDLF 2070 PGLDCPRVRY 2080 PDFNDAVEQV 2090 LEENGYAVLP 2100 IQVDKVVQMF 2110 ETMLTRHTTM 2120 VVGPTRGGKS 2130 VVINTLCQAQ 2140 TKLGLTTKLY 2150 ILNPKAVSVI 2160 ELYGILDPTT 2170 RDWTDGVLSN 2180 IFREINKPTD 2190 KKERKYILFD 2200 GDVDALWVEN 2210 MNSVMDDNRL 2220 LTLANGERIR 2230 LQAHCALLFE 2240 VGDLQYASPA 2250 TVSRCGMVYV 2260 DPKNLKYRPY 2270 WKKWVNQIPN 2280 KVEQYNLNSL 2290 FEKYVPYLMD 2300 VIVEGIVDGR 2310 QAEKLKTIVP 2320 QTDLNMVTQL 2330 AKMLDALLEG 2340 EIEDLDLLEC 2350 YFLEALYCSL 2360 GASLLEDGRM 2370 KFDEYIKRLA 2380 SLSTVDTEGV 2390 WANPGELPGQ 2400 LPTLYDFHFD 2410 NKRNQWVPWS 2420 KLVPEYIHAP 2430 ERKFINILVH 2440 TVDTTRTTWI 2450 LEQMVKIKQP 2460 VIFVGESGTS 2470 KTATTQNFLK 2480 NLSEETNIVL 2490 MVNFSSRTTS 2500 MDIQRNLEAN 2510 VEKRTKDTYG 2520 PPMGKRLLVF 2530 MDDMNMPRVD 2540 EYGTQQPIAL 2550 LKLLLEKGYL 2560 YDRGKELNCK 2570 SIRDLGFIAA 2580 MGKAGGGRNE 2590 VDPRFISLFS 2600 VFNVPFPSEE 2610 SLHLIYSSIL 2620 KGHTSTFHES 2630 IVAVSGKLTF 2640 CTLALYKNIV 2650 QDLPPTPSKF 2660 HYIFNLRDLS 2670 RVFNGLVLTN 2680 PERFQTVAQM 2690 VRVWRNECLR 2700 VFHDRLISET 2710 DKQLVQQHIG 2720 SLVVEHFKDD 2730 VEVVMRDPIL 2740 FGDFQMALHE 2750 GEPRIYEDIQ 2760 DYEAAKALFQ 2770 EILEEYNESN 2780 TKMNLVLFDD 2790 ALEHLTRVHR 2800 IIRMDRGHAL 2810 LVGVGGSGKQ 2820 SLSRLAAFTA 2830 SCEVFEILLS 2840 RGYSENSFRE 2850 DLKSLYLKLG 2860 IENKAMIFLF 2870 TDAHVAEEGF 2880 LELINNMLTS 2890 GIVPALFSEE 2900 EKESILSQIG 2910 QEALKQGMGP 2920 AKESVWQYFV 2930 NKSANNLHIV 2940 LGMSPVGDTL 2950 RTWCRNFPGM 2960 VNNTGIDWFM 2970 PWPPQALHAV 2980 AKSFLGYNPM 2990 IPAENIENVV 3000 KHVVLVHQSV 3010 DHYSQQFLQK 3020 LRRSNYVTPK 3030 NYLDFINTYS 3040 KLLDEKTQCN 3050 IAQCKRLDGG 3060 LDKLKEATIQ 3070 LDELNQKLAE 3080 QKIVLAEKSA 3090 ACEALLEEIA 3100 VNTAVAEEKK 3110 KLAEEKAMEI 3120 EEQNKVIAME 3130 KAEAETTLAE 3140 VMPILEAAKL 3150 ELQKLDKSDV 3160 TEIRSFAKPP 3170 KQVQTVCECI 3180 LIMKGYKELN 3190 WKTAKGVMSD 3200 PNFLRSLMEI 3210 DFDSITQSQV 3220 KNIKGLLKTL 3230 NTTTEEMEAV 3240 SKAGLGMLKF 3250 VEAVMGYCDV 3260 FREIKPKREK 3270 VARLERNFYL 3280 TKRELERIQN 3290 ELAAIQKELE 3300 TLGAKYEAAI 3310 LEKQKLQEEA 3320 EIMERRLIAA 3330 DKLISGLGSE 3340 NIRWLNDLDE 3350 LMHRRVKLLG 3360 DCLLCAAFLS 3370 YEGAFTWEFR 3380 DEMVNRIWQN 3390 DILEREIPLS 3400 QPFRLESLLT 3410 DDVEISRWGS 3420 QGLPPDELSV 3430 QNGILTTRAS 3440 RFPLCIDPQQ 3450 QALNWIKRKE 3460 EKNNLRVASF 3470 NDPDFLKQLE 3480 MSIKYGTPFL 3490 FRDVDEYIDP 3500 VIDNVLEKNI 3510 KVSQGRQFII 3520 LGDKEVDYDS 3530 NFRLYLNTKL 3540 ANPRYSPSVF 3550 GKAMVINYTV 3560 TLKGLEDQLL 3570 SVLVAYERRE 3580 LEEQREHLIQ 3590 ETSENKNLLK 3600 DLEDSLLREL 3610 ATSTGNMLDN 3620 VDLVHTLEET 3630 KSKATEVSEK 3640 LKLAEKTALD 3650 IDRLRDGYRP 3660 AARRGAILFF 3670 VLSEMALVNS 3680 MYQYSLIAFL 3690 EVFRLSLKKS 3700 LPDSILMKRL 3710 RNIMDTLTFS 3720 IYNHGCTGLF 3730 ERHKLLFSFN 3740 MTIKIEQAEG 3750 RVPQEELDFF 3760 LKGNISLEKS 3770 KRKKPCAWLS 3780 DQGWEDIILL 3790 SEMFSDNFGQ 3800 LPDDVENNQT 3810 VWQEWYDLDS 3820 LEQFPVPLGY 3830 DNNITPFQKL 3840 LILRCFRVDR 3850 VYRAVTDYVT 3860 VTMGEKYVQP 3870 PMISFEAIFE 3880 QSTPHSPIVF 3890 ILSPGSDPAT 3900 DLMKLAERSG 3910 FGGNRLKFLA 3920 MGQGQEKVAL 3930 QLLETAVARG 3940 QWLMLQNCHL 3950 LVKWLKDLEK 3960 SLERITKPHP 3970 DFRLWLTTDP 3980 TKGFPIGILQ 3990 KSLKVVTEPP 4000 NGLKLNMRAT 4010 YFKISHEMLD 4020 QCPHPAFKPL 4030 VYVLAFFHAV 4040 VQERRKFGKI 4050 GWNVYYDFNE 4060 SDFQVCMEIL 4070 NTYLTKAFQQ 4080 RDPRIPWGSL 4090 KYLIGEVMYG 4100 GRAIDSFDRR 4110 ILTIYMDEYL 4120 GDFIFDTFQP 4130 FHFFRNKEVD 4140 YKIPVGDEKE 4150 KFVEAIEALP 4160 LANTPEVFGL 4170 HPNAEIGYYT 4180 QAARDMWAHL 4190 LELQPQTGES 4200 SSGISRDDYI 4210 GQVAKEIENK 4220 MPKVFDLDQV 4230 RKRLGTGLSP 4240 TSVVLLQELE 4250 RFNKLVVRMT 4260 KSLAELQRAL 4270 AGEVGMSNEL 4280 DDVARSLFIG 4290 HIPNIWRRLA 4300 PDTLKSLGNW 4310 MVYFLRRFSQ 4320 YMLWVTESEP 4330 SVMWLSGLHI 4340 PESYLTALVQ 4350 ATCRKNGWPL 4360 DRSTLFTQVT 4370 KFQDADEVNE 4380 RAGQGCFVSG 4390 LYLEGADWDI 4400 EKGCLIKSKP 4410 KVLVVDLPIL 4420 KIIPIEAHRL 4430 KLQNTFRTPV 4440 YTTSMRRNAM 4450 GVGLVFEADL 4460 FTTRHISHWV 4470 LQGVCLTLNS D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005858 axonemal dynein complex
Cellular Component GO:0030286 dynein complex
Cellular Component GO:0005874 microtubule
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060294 cilium movement involved in cell motility

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.