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Overview

Uniprot IDQ8IVF7
Protein NameFormin-like protein 3
Gene NameFMNL3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
461 LRRLIKEKEEAFQRR

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignment

Protein Sequence

10 MGNLESAEGV 20 PGEPPSVPLL 30 LPPGKMPMPE 40 PCELEERFAL 50 VLSSMNLPPD 60 KARLLRQYDN 70 EKKWDLICDQ 80 ERFQVKNPPH 90 TYIQKLQSFL 100 DPSVTRKKFR 110 RRVQESTKVL 120 RELEISLRTN 130 HIGWVREFLN 140 DENKGLDVLV 150 DYLSFAQCSV 160 MFDFEGLESG 170 DDGAFDKLRS 180 WSRSIEDLQP 190 PSALSAPFTN 200 SLARSARQSV 210 LRYSTLPGRR 220 ALKNSRLVSQ 230 KDDVHVCILC 240 LRAIMNYQYG 250 FNLVMSHPHA 260 VNEIALSLNN 270 KNPRTKALVL 280 ELLAAVCLVR 290 GGHEIILAAF 300 DNFKEVCKEL 310 HRFEKLMEYF 320 RNEDSNIDFM 330 VACMQFINIV 340 VHSVEDMNFR 350 VHLQYEFTKL 360 GLEEFLQKSR 370 HTESEKLQVQ 380 IQAYLDNVFD 390 VGGLLEDAET 400 KNVALEKVEE 410 LEEHVSHLTE 420 KLLDLENENM 430 MRVAELEKQL 440 LQREKELESI 450 KETYENTSHQ 460 VHTLRRLIKE 470 KEEAFQRRCH 480 LEPNVRGLES 490 VDSEALARVG 500 PAELSEGMPP 510 SDLDLLAPAP 520 PPEEVLPLPP 530 PPAPPLPPPP 540 PPLPDKCPPA 550 PPLPGAAPSV 560 VLTVGLSAIR 570 IKKPIKTKFR 580 LPVFNWTALK 590 PNQISGTVFS 600 ELDDEKILED 610 LDLDKFEELF 620 KTKAQGPALD 630 LICSKNKTAQ 640 KAASKVTLLE 650 ANRAKNLAIT 660 LRKAGRSAEE 670 ICRAIHTFDL 680 QTLPVDFVEC 690 LMRFLPTEAE 700 VKLLRQYERE 710 RQPLEELAAE 720 DRFMLLFSKV 730 ERLTQRMAGM 740 AFLGNFQDNL 750 QMLTPQLNAI 760 IAASASVKSS 770 QKLKQMLEII 780 LALGNYMNSS 790 KRGAVYGFKL 800 QSLDLLLDTK 810 STDRKMTLLH 820 FIALTVKEKY 830 PDLANFWHEL 840 HFVEKAAAVS 850 LENVLLDVKE 860 LGRGMELIRR 870 ECSIHDNSVL 880 RNFLSTNEGK 890 LDKLQRDAKT 900 AEEAYNAVVR 910 YFGESPKTTP 920 PSVFFPVFVR 930 FIRSYKEAEQ 940 ENEARKKQEE 950 VMREKQLAQE 960 AKKLDAKTPS 970 QRNKWQQQEL 980 IAELRRRQAK 990 EHRPVYEGKD 1000 GTIEDIITVL 1010 KSVPFTARTA 1020 KRGSRFFCDA AHHDESNC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0032794 GTPase activating protein binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0001525 angiogenesis
Biological Process GO:0016477 cell migration
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0046847 filopodium assembly
Biological Process GO:0008360 regulation of cell shape

Reference

PMID: N/A