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Overview

Uniprot IDQ8IVT5
Protein NameKinase suppressor of Ras 1
Gene NameKSR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
61 SLRGLRTKCAVSNDL
903 SADINSSKVVPRFER

Function

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity)

Protein Sequence

10 MDRAALRAAA 20 MGEKKEGGGG 30 GDAAAAEGGA 40 GAAASRALQQ 50 CGQLQKLIDI 60 SIGSLRGLRT 70 KCAVSNDLTQ 80 QEIRTLEAKL 90 VRYICKQRQC 100 KLSVAPGERT 110 PELNSYPRFS 120 DWLYTFNVRP 130 EVVQEIPRDL 140 TLDALLEMNE 150 AKVKETLRRC 160 GASGDECGRL 170 QYALTCLRKV 180 TGLGGEHKED 190 SSWSSLDARR 200 ESGSGPSTDT 210 LSAASLPWPP 220 GSSQLGRAGN 230 SAQGPRSISV 240 SALPASDSPT 250 PSFSEGLSDT 260 CIPLHASGRL 270 TPRALHSFIT 280 PPTTPQLRRH 290 TKLKPPRTPP 300 PPSRKVFQLL 310 PSFPTLTRSK 320 SHESQLGNRI 330 DDVSSMRFDL 340 SHGSPQMVRR 350 DIGLSVTHRF 360 STKSWLSQVC 370 HVCQKSMIFG 380 VKCKHCRLKC 390 HNKCTKEAPA 400 CRISFLPLTR 410 LRRTESVPSD 420 INNPVDRAAE 430 PHFGTLPKAL 440 TKKEHPPAMN 450 HLDSSSNPSS 460 TTSSTPSSPA 470 PFPTSSNPSS 480 ATTPPNPSPG 490 QRDSRFNFPA 500 AYFIHHRQQF 510 IFPVPSAGHC 520 WKCLLIAESL 530 KENAFNISAF 540 AHAAPLPEAA 550 DGTRLDDQPK 560 ADVLEAHEAE 570 AEEPEAGKSE 580 AEDDEDEVDD 590 LPSSRRPWRG 600 PISRKASQTS 610 VYLQEWDIPF 620 EQVELGEPIG 630 QGRWGRVHRG 640 RWHGEVAIRL 650 LEMDGHNQDH 660 LKLFKKEVMN 670 YRQTRHENVV 680 LFMGACMNPP 690 HLAIITSFCK 700 GRTLHSFVRD 710 PKTSLDINKT 720 RQIAQEIIKG 730 MGYLHAKGIV 740 HKDLKSKNVF 750 YDNGKVVITD 760 FGLFGISGVV 770 REGRRENQLK 780 LSHDWLCYLA 790 PEIVREMTPG 800 KDEDQLPFSK 810 AADVYAFGTV 820 WYELQARDWP 830 LKNQAAEASI 840 WQIGSGEGMK 850 RVLTSVSLGK 860 EVSEILSACW 870 AFDLQERPSF 880 SLLMDMLEKL 890 PKLNRRLSHP 900 GHFWKSADIN 910 SSKVVPRFER 920 FGLGVLESSN PKM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0032587 ruffle membrane
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005078 MAP-kinase scaffold activity
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0043405 regulation of MAP kinase activity

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.