Search Results
Overview
| Uniprot ID | Q8IVW6 |
|---|---|
| Protein Name | AT-rich interactive domain-containing protein 3B |
| Gene Name | ARID3B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | KETQAASKYFHVQKV |
| 126 | SKYFHVQKVARQDPR |
| 388 | SPATTLRKGDGAPVT |
Function
Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A
Protein Sequence
10
MEPLQQQQQQ
20
QQQQQKQPHL
30
APLQMDAREK
40
QGQQMREAQF
50
LYAQKLVTQP
60
TLLSATAGRP
70
SGSTPLGPLA
80
RVPPTAAVAQ
90
VFERGNMNSE
100
PEEEDGGLED
110
EDGDDEVAEV
120
AEKETQAASK
130
YFHVQKVARQ
140
DPRVAPMSNL
150
LPAPGLPPHG
160
QQAKEDHTKD
170
ASKASPSVST
180
AGQPNWNLDE
190
QLKQNGGLAW
200
SDDADGGRGR
210
EISRDFAKLY
220
ELDGDPERKE
230
FLDDLFVFMQ
240
KRGTPINRIP
250
IMAKQILDLY
260
MLYKLVTEKG
270
GLVEIINKKI
280
WREITKGLNL
290
PTSITSAAFT
300
LRTQYMKYLY
310
AYECEKKALS
320
SPAELQAAID
330
GNRREGRRPS
340
YSSSLFGYSP
350
AAATAAAAAG
360
APALLSPPKI
370
RFPILGLGSS
380
SGTNTSSPRI
390
SPATTLRKGD
400
GAPVTTVPVP
410
NRLAVPVTLA
420
SQQAGTRTAA
430
LEQLRERLES
440
GEPAEKKASR
450
LSEEEQRLVQ
460
QAFQRNFFSM
470
ARQLPMKIRI
480
NGRAEDRAEA
490
SAAALNLTTS
500
SIGSINMSVD
510
IDGTTYAGVL
520
FAQKPVVHLI
530
TGSAPQSLGS
540
SASSSSSSHC
550
SPSPTSSRGT
560
PSAEPSTSWS
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.