Search Results
Overview
| Uniprot ID | Q8IW45 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | NAXD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 246 | GNVTVVQKGERDILS |
| 48 | LRKAHSIKDMENTLQ |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MVTRAGAGTA
20
VAGAVVVALL
30
SAALALYGPP
40
LDAVLERAFS
50
LRKAHSIKDM
60
ENTLQLVRNI
70
IPPLSSTKHK
80
GQDGRIGVVG
90
GCQEYTGAPY
100
FAAISALKVG
110
ADLSHVFCAS
120
AAAPVIKAYS
130
PELIVHPVLD
140
SPNAVHEVEK
150
WLPRLHALVV
160
GPGLGRDDAL
170
LRNVQGILEV
180
SKARDIPVVI
190
DADGLWLVAQ
200
QPALIHGYRK
210
AVLTPNHVEF
220
SRLYDAVLRG
230
PMDSDDSHGS
240
VLRLSQALGN
250
VTVVQKGERD
260
ILSNGQQVLV
270
CSQEGSSRRC
280
GGQGDLLSGS
290
LGVLVHWALL
300
AGPQKTNGSS
310
PLLVAAFGAC
320
SLTRQCNHQA
330
FQKHGRSTTT
340
SDMIAEVGAA
FSKLFET
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Biological Process | GO:0110051 | metabolite repair |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
| Biological Process | GO:1901847 | nicotinate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.