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Overview

Uniprot ID	Q8IWB6
Protein Name	Inactive serine/threonine-protein kinase TEX14
Gene Name	TEX14
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
466	LDGSVVKKAVVSGNY

Function

Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity)

Protein Sequence

10 MSRAVRLPVP 20 CPVQLGTLRN 30 DSLEAQLHEY 40 VKQGNYVKVK 50 KILKKGIYVD 60 AVNSLGQTAL 70 FVAALLGLRK 80 FVDVLVDYGS 90 DPNHRCFDGS 100 TPVHAAAFSG 110 NQWILSKLLD 120 AGGDLRLHDE 130 RGQNPKTWAL 140 TAGKERSTQI 150 VEFMQRCASH 160 MQAIIQGFSY 170 DLLKKIDSPQ 180 RLVYSPSWCG 190 GLVQGNPNGS 200 PNRLLKAGVI 210 SAQNIYSFGF 220 GKAMPWFQFY 230 LTGATQMAYL 240 GSLPVIGEKE 250 VIQADDEPTF 260 SFFSGPYMVM 270 TNLVWNGSRV 280 TVKELNLPTH 290 PHCSRLRLAD 300 LLIAEQEHSS 310 KLRHPYLLQL 320 MAVCLSQDLE 330 KTRLVYERIT 340 IGTLFSVLHE 350 RRSQFPVLHM 360 EVIVHLLLQI 370 SDALRYLHFQ 380 GFIHRSLSSY 390 AVHIISPGEA 400 RLTNLEYMLE 410 SEDRGVQRDL 420 TRVPLPTQLY 430 NWAAPEVILQ 440 KAATVKSDIY 450 SFSMIMQEIL 460 TDDIPWKGLD 470 GSVVKKAVVS 480 GNYLEADVRL 490 PKPYYDIVKS 500 GIHVKQKDRT 510 MNLQDIRYIL 520 KNDLKDFTGA 530 QRTQPTESPR 540 VQRYGLHPDV 550 NVYLGLTSEH 560 PRETPDMEII 570 ELKEMGSQPH 580 SPRVHSLFTE 590 GTLDPQAPDP 600 CLMARETQNQ 610 DAPCPAPFMA 620 EEASSPSTGQ 630 PSLCSFEINE 640 IYSGCLILED 650 DIEEPPGAAS 660 SLEADGPNQV 670 DELKSMEEEL 680 DKMEREACCF 690 GSEDESSSKA 700 ETEYSFDDWD 710 WQNGSLSSLS 720 LPESTREAKS 730 NLNNMSTTEE 740 YLISKCVLDL 750 KIMQTIMHEN 760 DDRLRNIEQI 770 LDEVEMKQKE 780 QEERMSLWAT 790 SREFTNAYKL 800 PLAVGPPSLN 810 YIPPVLQLSG 820 GQKPDTSGNY 830 PTLPRFPRML 840 PTLCDPGKQN 850 TDEQFQCTQG 860 AKDSLETSRI 870 QNTSSQGRPR 880 ESTAQAKATQ 890 FNSALFTLSS 900 HRQGPSASPS 910 CHWDSTRMSV 920 EPVSSEIYNA 930 ESRNKDDGKV 940 HLKWKMEVKE 950 MAKKAATGQL 960 TVPPWHPQSS 970 LTLESEAENE 980 PDALLQPPIR 990 SPENTDWQRV 1000 IEYHRENDEP 1010 RGNGKFDKTG 1020 NNDCDSDQHG 1030 RQPRLGSFTS 1040 IRHPSPRQKE 1050 QPEHSEAFQA 1060 SSDTLVAVEK 1070 SYSHQSMQST 1080 CSPESSEDIT 1090 DEFLTPDGEY 1100 FYSSTAQENL 1110 ALETSSPIEE 1120 DFEGIQGAFA 1130 QPQVSGEEKF 1140 QMRKILGKNA 1150 EILPRSQFQP 1160 VRSTEDEQEE 1170 TSKESPKELK 1180 EKDISLTDIQ 1190 DLSSISYEPD 1200 SSFKEASCKT 1210 PKINHAPTSV 1220 STPLSPGSVS 1230 SAASQYKDCL 1240 ESITFQVKTE 1250 FASCWNSQEF 1260 IQTLSDDFIS 1270 VRERAKKLDS 1280 LLTSSETPPS 1290 RLTGLKRLSS 1300 FIGAGSPSLV 1310 KACDSSPPHA 1320 TQRRSLPKVE 1330 AFSQHHIDEL 1340 PPPSQELLDD 1350 IELLKQQQGS 1360 STVLHENTAS 1370 DGGGTANDQR 1380 HLEEQETDSK 1390 KEDSSMLLSK 1400 ETEDLGEDTE 1410 RAHSTLDEDL 1420 ERWLQPPEES 1430 VELQDLPKGS 1440 ERETNIKDQK 1450 VGEEKRKRED 1460 SITPERRKSE 1470 GVLGTSEEDE 1480 LKSCFWKRLG 1490 WSESSRIIVL DQSDLSD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0045171	intercellular bridge
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0030496	midbody
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0008608	attachment of spindle microtubules to kinetochore
Biological Process	GO:0051301	cell division
Biological Process	GO:0043063	intercellular bridge organization
Biological Process	GO:0007140	male meiotic nuclear division
Biological Process	GO:0051306	mitotic sister chromatid separation
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling

Reference

PMID: N/A