Search Results

Overview

Uniprot ID	Q8IWB9
Protein Name	Testis-expressed protein 2
Gene Name	TEX2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
248	KLNLHLFKQFTQPRN

Function

During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation

Protein Sequence

10 MTSLYGRHAE 20 KTTDMPKPSA 30 PKVHVQRSVS 40 RDTIAIHFSA 50 SGEEEEEEEE 60 EFREYFEEGL 70 DDQSIVTGLE 80 AKEDLYLEPQ 90 VGHDPAGPAA 100 SPVLADGLSV 110 SQAPAILPVS 120 KNTVKLLESP 130 VPAAQVLSTV 140 PLAVSPGSSS 150 SGPLASSPSV 160 SSLSEQKTSS 170 SSPLSSPSKS 180 PILSSSASTS 190 TLSSAKPFMS 200 LVKSLSTEVE 210 PKESPHPARH 220 RHLMKTLVKS 230 LSTDTSRQES 240 DTVSYKPPDS 250 KLNLHLFKQF 260 TQPRNTGGDS 270 KTAPSSPLTS 280 PSDTRSFFKV 290 PEMEAKIEDT 300 KRRLSEVIYE 310 PFQLLSKIIG 320 EESGSHRPKA 330 LSSSASELSN 340 LSSLNGHLES 350 NNNYSIKEEE 360 CDSEGDGYGS 370 DSNIPRSDHP 380 KSTGEPTREI 390 ELKSSQGSSL 400 KDLGLKTSSL 410 VLEKCSLSAL 420 VSKEDEEFCE 430 LYTEDFDLET 440 EGESKVDKLS 450 DIPLKPEVLA 460 EDGVVLDSED 470 EVDSAVQHPE 480 LPVKTLGFFI 490 MCVYVYLILP 500 LPHYVSGLFL 510 GIGLGFMTAV 520 CVIWFFTPPS 530 AHKYHKLHKN 540 LRHWNTRSLD 550 IKEPEILKGW 560 MNEIYNYDPE 570 TYHATLTHSV 580 FVRLEGGTLR 590 LSKPNKNISR 600 RASYNEPKPE 610 VTYISQKIYD 620 LSDSKIYLVP 630 KTLARKRIWN 640 KKYPICIELG 650 QQDDFMSKAQ 660 TDKETSEEKP 670 PAEGSEDPKK 680 PPRPQEGTRS 690 SQRDQILYLF 700 GRTGREKEEW 710 FRRFILASKL 720 KSEIKKSSGV 730 SGGKPGLLPA 740 HSRHNSPSGH 750 LTHSRSSSKG 760 SVEEIMSQPK 770 QKELAGSVRQ 780 KMLLDYSVYM 790 GRCVPQESRS 800 PQRSPLQSAE 810 SSPTAGKKLP 820 EVPPSEEEEQ 830 EAWVNALLGR 840 IFWDFLGEKY 850 WSDLVSKKIQ 860 MKLSKIKLPY 870 FMNELTLTEL 880 DMGVAVPKIL 890 QAFKPYVDHQ 900 GLWIDLEMSY 910 NGSFLMTLET 920 KMNLTKLGKE 930 PLVEALKVGE 940 IGKEGCRPRA 950 FCLADSDEES 960 SSAGSSEEDD 970 APEPSGGDKQ 980 LLPGAEGYVG 990 GHRTSKIMRF 1000 VDKITKSKYF 1010 QKATETEFIK 1020 KKIEEVSNTP 1030 LLLTVEVQEC 1040 RGTLAVNIPP 1050 PPTDRVWYGF 1060 RKPPHVELKA 1070 RPKLGEREVT 1080 LVHVTDWIEK 1090 KLEQEFQKVF 1100 VMPNMDDVYI 1110 TIMHSAMDPR 1120 STSCLLKDPP VEAADQP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0031965	nuclear membrane
Molecular Function	GO:0008289	lipid binding
Biological Process	GO:0006869	lipid transport
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0006665	sphingolipid metabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.