Search Results

Overview

Uniprot IDQ8IWI9
Protein NameMAX gene-associated protein
Gene NameMGA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1091 KRKVVLVKGGSKTKH
1133 REEEEQLKEKKKRKK
1139 LKEKKKRKKLEYTIC
1140 KEKKKRKKLEYTICE
1201 LSPTVKGKLLTGIKS
1207 GKLLTGIKSPRSYTP
1310 KLQEKSWKSSCNEGE
1386 QRKSRGEKNPPVYSS
1502 LPSTSNSKMASSSGT
1525 LKAFVPAKRPIAARP
2103 KTVQNLSKVQHQKLG
2108 LSKVQHQKLGDVKVE
2179 ERWRKHLKGPLTRKC
2185 LKGPLTRKCVGASQE
2378 AAHTQSFKQPSCTHI
2397 KAAERSRKAPPIPLK
2746 AQEFLPKKISGDMRG
2777 SKDSSFHKLKMKDLK
2866 ARRAFISKVPPGSRA
2988 TLWRPMPKLAPLGLK
3041 DQEGRESKVMPTLAP
455 SSPSGVAKAKMFKLD
457 PSGVAKAKMFKLDTG
542 PDLRVVQKYPLLKEP
592 RKRTTMLKIATAAKV
598 LKIATAAKVVNANQN
613 ASPNVPGKRGRPRKL
634 RPPKNTGKSLISTKN
785 PFVSRTGKTNDFTKI
793 TNDFTKIKGWRGKFH
817 GNSESSLKNRSAFCS
874 TLDSVLKKQSTISPS
916 GRTKSSYKSILPYPV
937 SHVILGDKVTKNSSG
990 SRPPGLSKSQVKLMD

Function

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity)

Protein Sequence

10 MEEKQQIILA 20 NQDGGTVAGA 30 APTFFVILKQ 40 PGNGKTDQGI 50 LVTNQDACAL 60 ASSVSSPVKS 70 KGKICLPADC 80 TVGGITVTLD 90 NNSMWNEFYH 100 RSTEMILTKQ 110 GRRMFPYCRY 120 WITGLDSNLK 130 YILVMDISPV 140 DNHRYKWNGR 150 WWEPSGKAEP 160 HVLGRVFIHP 170 ESPSTGHYWM 180 HQPVSFYKLK 190 LTNNTLDQEG 200 HIILHSMHRY 210 LPRLHLVPAE 220 KAVEVIQLNG 230 PGVHTFTFPQ 240 TEFFAVTAYQ 250 NIQITQLKID 260 YNPFAKGFRD 270 DGLNNKPQRD 280 GKQKNSSDQE 290 GNNISSSSGH 300 RVRLTEGQGS 310 EIQPGDLDPL 320 SRGHETSGKG 330 LEKTSLNIKR 340 DFLGFMDTDS 350 ALSEVPQLKQ 360 EISECLIASS 370 FEDDSRVASP 380 LDQNGSFNVV 390 IKEEPLDDYD 400 YELGECPEGV 410 TVKQEETDEE 420 TDVYSNSDDD 430 PILEKQLKRH 440 NKVDNPEADH 450 LSSKWLPSSP 460 SGVAKAKMFK 470 LDTGKMPVVY 480 LEPCAVTRST 490 VKISELPDNM 500 LSTSRKDKSS 510 MLAELEYLPT 520 YIENSNETAF 530 CLGKESENGL 540 RKHSPDLRVV 550 QKYPLLKEPQ 560 WKYPDISDSI 570 STERILDDSK 580 DSVGDSLSGK 590 EDLGRKRTTM 600 LKIATAAKVV 610 NANQNASPNV 620 PGKRGRPRKL 630 KLCKAGRPPK 640 NTGKSLISTK 650 NTPVSPGSTF 660 PDVKPDLEDV 670 DGVLFVSFES 680 KEALDIHAVD 690 GTTEESSSLQ 700 ASTTNDSGYR 710 ARISQLEKEL 720 IEDLKTLRHK 730 QVIHPGLQEV 740 GLKLNSVDPT 750 MSIDLKYLGV 760 QLPLAPATSF 770 PFWNLTGTNP 780 ASPDAGFPFV 790 SRTGKTNDFT 800 KIKGWRGKFH 810 SASASRNEGG 820 NSESSLKNRS 830 AFCSDKLDEY 840 LENEGKLMET 850 SMGFSSNAPT 860 SPVVYQLPTK 870 STSYVRTLDS 880 VLKKQSTISP 890 STSYSLKPHS 900 VPPVSRKAKS 910 QNRQATFSGR 920 TKSSYKSILP 930 YPVSPKQKYS 940 HVILGDKVTK 950 NSSGIISENQ 960 ANNFVVPTLD 970 ENIFPKQISL 980 RQAQQQQQQQ 990 QGSRPPGLSK 1000 SQVKLMDLED 1010 CALWEGKPRT 1020 YITEERADVS 1030 LTTLLTAQAS 1040 LKTKPIHTII 1050 RKRAPPCNND 1060 FCRLGCVCSS 1070 LALEKRQPAH 1080 CRRPDCMFGC 1090 TCLKRKVVLV 1100 KGGSKTKHFQ 1110 RKAAHRDPVF 1120 YDTLGEEARE 1130 EEEGIREEEE 1140 QLKEKKKRKK 1150 LEYTICETEP 1160 EQPVRHYPLW 1170 VKVEGEVDPE 1180 PVYIPTPSVI 1190 EPMKPLLLPQ 1200 PEVLSPTVKG 1210 KLLTGIKSPR 1220 SYTPKPNPVI 1230 REEDKDPVYL 1240 YFESMMTCAR 1250 VRVYERKKED 1260 QRQPSSSSSP 1270 SPSFQQQTSC 1280 HSSPENHNNA 1290 KEPDSEQQPL 1300 KQLTCDLEDD 1310 SDKLQEKSWK 1320 SSCNEGESSS 1330 TSYMHQRSPG 1340 GPTKLIEIIS 1350 DCNWEEDRNK 1360 ILSILSQHIN 1370 SNMPQSLKVG 1380 SFIIELASQR 1390 KSRGEKNPPV 1400 YSSRVKISMP 1410 SCQDQDDMAE 1420 KSGSETPDGP 1430 LSPGKMEDIS 1440 PVQTDALDSV 1450 RERLHGGKGL 1460 PFYAGLSPAG 1470 KLVAYKRKPS 1480 SSTSGLIQVA 1490 SNAKVAASRK 1500 PRTLLPSTSN 1510 SKMASSSGTA 1520 TNRPGKNLKA 1530 FVPAKRPIAA 1540 RPSPGGVFTQ 1550 FVMSKVGALQ 1560 QKIPGVSTPQ 1570 TLAGTQKFSI 1580 RPSPVMVVTP 1590 VVSSEPVQVC 1600 SPVTAAVTTT 1610 TPQVFLENTT 1620 AVTPMTAISD 1630 VETKETTYSS 1640 GATTTGVVEV 1650 SETNTSTSVT 1660 STQSTATVNL 1670 TKTTGITTPV 1680 ASVAFPKSLV 1690 ASPSTITLPV 1700 ASTASTSLVV 1710 VTAAASSSMV 1720 TTPTSSLGSV 1730 PIILSGINGS 1740 PPVSQRPENA 1750 AQIPVATPQV 1760 SPNTVKRAGP 1770 RLLLIPVQQG 1780 SPTLRPVSNT 1790 QLQGHRMVLQ 1800 PVRSPSGMNL 1810 FRHPNGQIVQ 1820 LLPLHQLRGS 1830 NTQPNLQPVM 1840 FRNPGSVMGI 1850 RLPAPSKPSE 1860 TPPSSTSSSA 1870 FSVMNPVIQA 1880 VGSSSAVNVI 1890 TQAPSLLSSG 1900 ASFVSQAGTL 1910 TLRISPPEPQ 1920 SFASKTGSET 1930 KITYSSGGQP 1940 VGTASLIPLQ 1950 SGSFALLQLP 1960 GQKPVPSSIL 1970 QHVASLQMKR 1980 ESQNPDQKDE 1990 TNSIKREQET 2000 KKVLQSEGEA 2010 VDPEANVIKQ 2020 NSGAATSEET 2030 LNDSLEDRGD 2040 HLDEECLPEE 2050 GCATVKPSEH 2060 SCITGSHTDQ 2070 DYKDVNEEYG 2080 ARNRKSSKEK 2090 VAVLEVRTIS 2100 EKASNKTVQN 2110 LSKVQHQKLG 2120 DVKVEQQKGF 2130 DNPEENSSEF 2140 PVTFKEESKF 2150 ELSGSKVMEQ 2160 QSNLQPEAKE 2170 KECGDSLEKD 2180 RERWRKHLKG 2190 PLTRKCVGAS 2200 QECKKEADEQ 2210 LIKETKTCQE 2220 NSDVFQQEQG 2230 ISDLLGKSGI 2240 TEDARVLKTE 2250 CDSWSRISNP 2260 SAFSIVPRRA 2270 AKSSRGNGHF 2280 QGHLLLPGEQ 2290 IQPKQEKKGG 2300 RSSADFTVLD 2310 LEEDDEDDNE 2320 KTDDSIDEIV 2330 DVVSDYQSEE 2340 VDDVEKNNCV 2350 EYIEDDEEHV 2360 DIETVEELSE 2370 EINVAHLKTT 2380 AAHTQSFKQP 2390 SCTHISADEK 2400 AAERSRKAPP 2410 IPLKLKPDYW 2420 SDKLQKEAEA 2430 FAYYRRTHTA 2440 NERRRRGEMR 2450 DLFEKLKITL 2460 GLLHSSKVSK 2470 SLILTRAFSE 2480 IQGLTDQADK 2490 LIGQKNLLTR 2500 KRNILIRKVS 2510 SLSGKTEEVV 2520 LKKLEYIYAK 2530 QQALEAQKRK 2540 KKMGSDEFDI 2550 SPRISKQQEG 2560 SSASSVDLGQ 2570 MFINNRRGKP 2580 LILSRKKDQA 2590 TENTSPLNTP 2600 HTSANLVMTP 2610 QGQLLTLKGP 2620 LFSGPVVAVS 2630 PDLLESDLKP 2640 QVAGSAVALP 2650 ENDDLFMMPR 2660 IVNVTSLATE 2670 GGLVDMGGSK 2680 YPHEVPDSKP 2690 SDHLKDTVRN 2700 EDNSLEDKGR 2710 ISSRGNRDGR 2720 VTLGPTQVFL 2730 ANKDSGYPQI 2740 VDVSNMQKAQ 2750 EFLPKKISGD 2760 MRGIQYKWKE 2770 SESRGERVKS 2780 KDSSFHKLKM 2790 KDLKDSSIEM 2800 ELRKVTSAIE 2810 EAALDSSELL 2820 TNMEDEDDTD 2830 ETLTSLLNEI 2840 AFLNQQLNDD 2850 SVGLAELPSS 2860 MDTEFPGDAR 2870 RAFISKVPPG 2880 SRATFQVEHL 2890 GTGLKELPDV 2900 QGESDSISPL 2910 LLHLEDDDFS 2920 ENEKQLAEPA 2930 SEPDVLKIVI 2940 DSEIKDSLLS 2950 NKKAIDGGKN 2960 TSGLPAEPES 2970 VSSPPTLHMK 2980 TGLENSNSTD 2990 TLWRPMPKLA 3000 PLGLKVANPS 3010 SDADGQSLKV 3020 MPCLAPIAAK 3030 VGSVGHKMNL 3040 TGNDQEGRES 3050 KVMPTLAPVV 3060 AKLGNSGASP SSAGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0071339 MLL1 complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0001708 cell fate specification
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.