Search Results

Overview

Uniprot ID	Q8IWJ2
Protein Name	GRIP and coiled-coil domain-containing protein 2
Gene Name	GCC2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
797	LAKINEEKCNLAFQR
934	LLKDSLAKSPSVKND

Function

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2

Protein Sequence

10 MEDLVQDGVA 20 SPATPGTGKS 30 KLETLPKEDL 40 IKFAKKQMML 50 IQKAKSRCTE 60 LEKEIEELRS 70 KPVTEGTGDI 80 IKALTERLDA 90 LLLEKAETEQ 100 QCLSLKKENI 110 KMKQEVEDSV 120 TKMGDAHKEL 130 EQSHINYVKE 140 IENLKNELMA 150 VRSKYSEDKA 160 NLQKQLEEAM 170 NTQLELSEQL 180 KFQNNSEDNV 190 KKLQEEIEKI 200 RPGFEEQILY 210 LQKQLDATTD 220 EKKETVTQLQ 230 NIIEANSQHY 240 QKNINSLQEE 250 LLQLKAIHQE 260 EVKELMCQIE 270 ASAKEHEAEI 280 NKLNELKENL 290 VKQCEASEKN 300 IQKKYECELE 310 NLRKATSNAN 320 QDNQICSILL 330 QENTFVEQVV 340 NEKVKHLEDT 350 LKELESQHSI 360 LKDEVTYMNN 370 LKLKLEMDAQ 380 HIKDEFFHER 390 EDLEFKINEL 400 LLAKEEQGCV 410 IEKLKSELAG 420 LNKQFCYTVE 430 QHNREVQSLK 440 EQHQKEISEL 450 NETFLSDSEK 460 EKLTLMFEIQ 470 GLKEQCENLQ 480 QEKQEAILNY 490 ESLREIMEIL 500 QTELGESAGK 510 ISQEFESMKQ 520 QQASDVHELQ 530 QKLRTAFTEK 540 DALLETVNRL 550 QGENEKLLSQ 560 QELVPELENT 570 IKNLQEKNGV 580 YLLSLSQRDT 590 MLKELEGKIN 600 SLTEEKDDFI 610 NKLKNSHEEM 620 DNFHKKCERE 630 ERLILELGKK 640 VEQTIQYNSE 650 LEQKVNELTG 660 GLEETLKEKD 670 QNDQKLEKLM 680 VQMKVLSEDK 690 EVLSAEVKSL 700 YEENNKLSSE 710 KKQLSRDLEV 720 FLSQKEDVIL 730 KEHITQLEKK 740 LQLMVEEQDN 750 LNKLLENEQV 760 QKLFVKTQLY 770 GFLKEMGSEV 780 SEDSEEKDVV 790 NVLQAVGESL 800 AKINEEKCNL 810 AFQRDEKVLE 820 LEKEIKCLQE 830 ESVVQCEELK 840 SLLRDYEQEK 850 VLLRKELEEI 860 QSEKEALQSD 870 LLEMKNANEK 880 TRLENQNLLI 890 QVEEVSQTCS 900 KSEIHNEKEK 910 CFIKEHENLK 920 PLLEQKELRD 930 RRAELILLKD 940 SLAKSPSVKN 950 DPLSSVKELE 960 EKIENLEKEC 970 KEKEEKINKI 980 KLVAVKAKKE 990 LDSSRKETQT 1000 VKEELESLRS 1010 EKDQLSASMR 1020 DLIQGAESYK 1030 NLLLEYEKQS 1040 EQLDVEKERA 1050 NNFEHRIEDL 1060 TRQLRNSTLQ 1070 CETINSDNED 1080 LLARIETLQS 1090 NAKLLEVQIL 1100 EVQRAKAMVD 1110 KELEAEKLQK 1120 EQKIKEHATT 1130 VNELEELQVQ 1140 LQKQKKQLQK 1150 TMQELELVKK 1160 DAQQTTLMNM 1170 EIADYERLMK 1180 ELNQKLTNKN 1190 NKIEDLEQEI 1200 KIQKQKQETL 1210 QEEITSLQSS 1220 VQQYEEKNTK 1230 IKQLLVKTKK 1240 ELADSKQAET 1250 DHLILQASLK 1260 GELEASQQQV 1270 EVYKIQLAEI 1280 TSEKHKIHEH 1290 LKTSAEQHQR 1300 TLSAYQQRVT 1310 ALQEECRAAK 1320 AEQATVTSEF 1330 ESYKVRVHNV 1340 LKQQKNKSMS 1350 QAETEGAKQE 1360 REHLEMLIDQ 1370 LKIKLQDSQN 1380 NLQINVSELQ 1390 TLQSEHDTLL 1400 ERHNKMLQET 1410 VSKEAELREK 1420 LCSIQSENMM 1430 MKSEHTQTVS 1440 QLTSQNEVLR 1450 NSFRDQVRHL 1460 QEEHRKTVET 1470 LQQQLSKMEA 1480 QLFQLKNEPT 1490 TRSPVSSQQS 1500 LKNLRERRNT 1510 DLPLLDMHTV 1520 TREEGEGMET 1530 TDTESVSSAS 1540 TYTQSLEQLL 1550 NSPETKLEPP 1560 LWHAEFTKEE 1570 LVQKLSSTTK 1580 SADHLNGLLR 1590 ETEATNAILM 1600 EQIKLLKSEI 1610 RRLERNQERE 1620 KSAANLEYLK 1630 NVLLQFIFLK 1640 PGSERERLLP 1650 VINTMLQLSP 1660 EEKGKLAAVA 1670 QGEEENASRS 1680 SGWASYLHSW SGLR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0090161	Golgi ribbon formation
Biological Process	GO:0034499	late endosome to Golgi transport
Biological Process	GO:0034453	microtubule anchoring
Biological Process	GO:0031023	microtubule organizing center organization
Biological Process	GO:0034067	protein localization to Golgi apparatus
Biological Process	GO:0006622	protein targeting to lysosome
Biological Process	GO:0071955	recycling endosome to Golgi transport
Biological Process	GO:0070861	regulation of protein exit from endoplasmic reticulum
Biological Process	GO:0042147	retrograde transport, endosome to Golgi

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.