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Overview

Uniprot IDQ8IWW6
Protein NameRho GTPase-activating protein 12
Gene NameARHGAP12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
419 QEPIVLTKWRHSTIV
614 PKKLRSFKVSSIDSS

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state

Protein Sequence

10 MKMADRSGKI 20 IPGQVYIEVE 30 YDYEYEAKDR 40 KIVIKQGERY 50 ILVKKTNDDW 60 WQVKPDENSK 70 AFYVPAQYVK 80 EVTRKALMPP 90 VKQVAGLPNN 100 STKIMQSLHL 110 QRSTENVNKL 120 PELSSFGKPS 130 SSVQGTGLIR 140 DANQNFGPSY 150 NQGQTVNLSL 160 DLTHNNGKFN 170 NDSHSPKVSS 180 QNRTRSFGHF 190 PGPEFLDVEK 200 TSFSQEQSCD 210 SAGEGSERIH 220 QDSESGDELS 230 SSSTEQIRAT 240 TPPNQGRPDS 250 PVYANLQELK 260 ISQSALPPLP 270 GSPAIQINGE 280 WETHKDSSGR 290 CYYYNRGTQE 300 RTWKPPRWTR 310 DASISKGDFQ 320 NPGDQELLSS 330 EENYYSTSYS 340 QSDSQCGSPP 350 RGWSEELDER 360 GHTLYTSDYT 370 NEKWLKHVDD 380 QGRQYYYSAD 390 GSRSEWELPK 400 YNASSQQQRE 410 IIKSRSLDRR 420 LQEPIVLTKW 430 RHSTIVLDTN 440 DKESPTASKP 450 CFPENESSPS 460 SPKHQDTASS 470 PKDQEKYGLL 480 NVTKIAENGK 490 KVRKNWLSSW 500 AVLQGSSLLF 510 TKTQGSSTSW 520 FGSNQSKPEF 530 TVDLKGATIE 540 MASKDKSSKK 550 NVFELKTRQG 560 TELLIQSDND 570 TVINDWFKVL 580 SSTINNQAVE 590 TDEGIEEEIP 600 DSPGIEKHDK 610 EKEQKDPKKL 620 RSFKVSSIDS 630 SEQKKTKKNL 640 KKFLTRRPTL 650 QAVREKGYIK 660 DQVFGSNLAN 670 LCQRENGTVP 680 KFVKLCIEHV 690 EEHGLDIDGI 700 YRVSGNLAVI 710 QKLRFAVNHD 720 EKLDLNDSKW 730 EDIHVITGAL 740 KMFFRELPEP 750 LFTFNHFNDF 760 VNAIKQEPRQ 770 RVAAVKDLIR 780 QLPKPNQDTM 790 QILFRHLRRV 800 IENGEKNRMT 810 YQSIAIVFGP 820 TLLKPEKETG 830 NIAVHTVYQN 840 QIVELILLEL SSIFGR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0001891 phagocytic cup
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005096 GTPase activator activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0002011 morphogenesis of an epithelial sheet
Biological Process GO:0051058 negative regulation of small GTPase mediated signal transduction
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.