Search Results

Overview

Uniprot IDQ8IWX8
Protein NameCalcium homeostasis endoplasmic reticulum protein
Gene NameCHERP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
844 SRLGEENKGHQMLVK
851 KGHQMLVKMGWSGSG
872 QGIQDPIKGGDVRDK
879 KGGDVRDKWDQYKGV
901 YENYRRNKSYSFIAR

Function

Involved in calcium homeostasis, growth and proliferation

Protein Sequence

10 MEMPLPPDDQ 20 ELRNVIDKLA 30 QFVARNGPEF 40 EKMTMEKQKD 50 NPKFSFLFGG 60 EFYSYYKCKL 70 ALEQQQLICK 80 QQTPELEPAA 90 TMPPLPQPPL 100 APAAPIPPAQ 110 GAPSMDELIQ 120 QSQWNLQQQE 130 QHLLALRQEQ 140 VTAAVAHAVE 150 QQMQKLLEET 160 QLDMNEFDNL 170 LQPIIDTCTK 180 DAISAGKNWM 190 FSNAKSPPHC 200 ELMAGHLRNR 210 ITADGAHFEL 220 RLHLIYLIND 230 VLHHCQRKQA 240 RELLAALQKV 250 VVPIYCTSFL 260 AVEEDKQQKI 270 ARLLQLWEKN 280 GYFDDSIIQQ 290 LQSPALGLGQ 300 YQATLINEYS 310 SVVQPVQLAF 320 QQQIQTLKTQ 330 HEEFVTSLAQ 340 QQQQQQQQQQ 350 QLQMPQMEAE 360 VKATPPPPAP 370 PPAPAPAPAI 380 PPTTQPDDSK 390 PPIQMPGSSE 400 YEAPGGVQDP 410 AAAGPRGPGP 420 HDQIPPNKPP 430 WFDQPHPVAP 440 WGQQQPPEQP 450 PYPHHQGGPP 460 HCPPWNNSHE 470 GMWGEQRGDP 480 GWNGQRDAPW 490 NNQPDAAWNS 500 QFEGPWNSQH 510 EQPPWGGGQR 520 EPPFRMQRPP 530 HFRGPFPPHQ 540 QHPQFNQPPH 550 PHNFNRFPPR 560 FMQDDFPPRH 570 PFERPPYPHR 580 FDYPQGDFPA 590 EMGPPHHHPG 600 HRMPHPGINE 610 HPPWAGPQHP 620 DFGPPPHGFN 630 GQPPHMRRQG 640 PPHINHDDPS 650 LVPNVPYFDL 660 PAGLMAPLVK 670 LEDHEYKPLD 680 PKDIRLPPPM 690 PPSERLLAAV 700 EAFYSPPSHD 710 RPRNSEGWEQ 720 NGLYEFFRAK 730 MRARRRKGQE 740 KRNSGPSRSR 750 SRSKSRGRSS 760 SRSNSRSSKS 770 SGSYSRSRSR 780 SCSRSYSRSR 790 SRSRSRSRSS 800 RSRSRSQSRS 810 RSKSYSPGRR 820 RRSRSRSPTP 830 PSSAGLGSNS 840 APPIPDSRLG 850 EENKGHQMLV 860 KMGWSGSGGL 870 GAKEQGIQDP 880 IKGGDVRDKW 890 DQYKGVGVAL 900 DDPYENYRRN 910 KSYSFIARMK ARDECK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0007399 nervous system development
Biological Process GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0006396 RNA processing
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0044325 transmembrane transporter binding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.