Search Results

Overview

Uniprot IDQ8IWZ8
Protein NameSURP and G-patch domain-containing protein 1
Gene NameSUGP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
150 VKSYSHAKQLPVAHR
27 VAPPKSGKMNMNILH
380 PASAATVKRKRKSRW
419 PLSVQDLKGLGYEKG
49 KKREIEAKMEQKAKQ
594 GIKNPVNKGTTTVDG
95 SFLQQFLKLQKAQTS
98 QQFLKLQKAQTSTDA

Function

Plays a role in pre-mRNA splicing

Protein Sequence

10 MSLKMDNRDV 20 AGKANRWFGV 30 APPKSGKMNM 40 NILHQEELIA 50 QKKREIEAKM 60 EQKAKQNQVA 70 SPQPPHPGEI 80 TNAHNSSCIS 90 NKFANDGSFL 100 QQFLKLQKAQ 110 TSTDAPTSAP 120 SAPPSTPTPS 130 AGKRSLLISR 140 RTGLGLASLP 150 GPVKSYSHAK 160 QLPVAHRPSV 170 FQSPDEDEEE 180 DYEQWLEIKV 190 SPPEGAETRK 200 VIEKLARFVA 210 EGGPELEKVA 220 MEDYKDNPAF 230 AFLHDKNSRE 240 FLYYRKKVAE 250 IRKEAQKSQA 260 ASQKVSPPED 270 EEVKNLAEKL 280 ARFIADGGPE 290 VETIALQNNR 300 ENQAFSFLYE 310 PNSQGYKYYR 320 QKLEEFRKAK 330 ASSTGSFTAP 340 DPGLKRKSPP 350 EALSGSLPPA 360 TTCPASSTPA 370 PTIIPAPAAP 380 GKPASAATVK 390 RKRKSRWGPE 400 EDKVELPPAE 410 LVQRDVDASP 420 SPLSVQDLKG 430 LGYEKGKPVG 440 LVGVTELSDA 450 QKKQLKEQQE 460 MQQMYDMIMQ 470 HKRAMQDMQL 480 LWEKAVQQHQ 490 HGYDSDEEVD 500 SELGTWEHQL 510 RRMEMDKTRE 520 WAEQLTKMGR 530 GKHFIGDFLP 540 PDELEKFMET 550 FKALKEGREP 560 DYSEYKEFKL 570 TVENIGYQML 580 MKMGWKEGEG 590 LGSEGQGIKN 600 PVNKGTTTVD 610 GAGFGIDRPA 620 ELSKEDDEYE 630 AFRKRMMLAY 640 RFRPNPLNNP RRPYY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.